Evidence map›Paper›PMID 30381356›Full record

ArticlemSphere2018

Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens.

Zeinab Mamouei, Abdullah Alqarihi, Shakti Singh, Shuying Xu, Michael K Mansour, Ashraf S Ibrahim, Priya Uppuluri

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Antifungal activity of cephalosporins as an alternative for the combat of Candida auris.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  5. Article
  6. Article
  7. Identification of a Drug Candidate againstJournal of microbiology and biotechnology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Host immune response against fungal biofilms.Current opinion in microbiology · 2024
    Review
  13. Article
  14. Article
  15. Review
  16. Antifungal therapy ofBiofilm · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Zeinab MamoueiLos Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, California, USA.
Abdullah AlqarihiLos Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, California, USA.
Shakti SinghLos Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, California, USA.
Shuying XuDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.
Michael K MansourDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.
Ashraf S IbrahimLos Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, California, USA.
Priya UppuluriLos Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, California, USA puppuluri@labiomed.org.
University of California, Los Angeles · USMassachusetts General Hospital · USUCLA Medical Center · US

Funding

Novel Toxins and Receptors in Mucormycosis Pathogenesis and TreatmentR01AI063503 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI IBRAHIM, ASHRAF S. · 2006 to 2025
$7.3M
The role of spleen tyrosine kinase (syk) in neutrophil responses to pathogenic fungi.R01AI132638 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MANSOUR, MICHAEL K · 2018 to 2021
$1.6M
NIAID NIH HHS R01 AI063503NIAID NIH HHS R01 AI132638
6 · The paper itself

Abstract

Invasive fungal infections due to

Indexed as

AnimalsAntifungal AgentsAspergillus fumigatusBiguanidesBiofilmsCandidaCandida albicansCentral Venous CathetersDrug Evaluation, PreclinicalDrug SynergismFluconazoleMiceMicrobial ViabilityModels, AnimalSmall Molecule LibrariesalexidineAntifungal AgentsBiguanidesFluconazoleSmall Molecule Librariesantifungal agentsbiofilmsCandida albicansFDAHTSpanfungal

Identifiers

PMID30381356
PMCPMC6211222
OpenAlexW2952183412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.