Evidence map›Paper›PMID 30381350›Full record

ArticlemSphere2018

A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis.

Kiranmai Bhatt, Henrique Machado, Nuno S Osório, Jeremy Sousa, Filipa Cardoso, Carlos Magalhães, Bing Chen, Mei Chen, John Kim, Albel Singh and 6 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

  1. Kupyaphores─Self-Assembling Diisocyanolipopeptide ZnJournal of the American Chemical Society · 2025
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  2. Population structure ofMicrobial genomics · 2025
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  5. Copper-chelating natural products.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Review
  6. Biosynthesis of isonitrile lipopeptides.Current opinion in chemical biology · 2024
    Review
  7. Article
  8. Vitamin BMicrobiology spectrum · 2024
    Article
  9. Article
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  11. Article
  12. Article
  13. Kupyaphores are zinc homeostatic metallophores required for colonization ofProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. Article
  15. A Role forInternational journal of molecular sciences · 2021
    Article
  16. Microorganisms · 2021
    Article
  17. Heterogeneous Streptomycin Resistance Level AmongFrontiers in microbiology · 2021
    Article
  18. Unique Features ofFrontiers in microbiology · 2021
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Kiranmai Bhatt *Heart of England NHS Trust, Birmingham, United Kingdom.
Henrique Machado *ICVS, University of Minho, Braga, Portugal.
Nuno S OsórioICVS, University of Minho, Braga, Portugal.
Jeremy Sousai3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal.
Filipa CardosoICVS, University of Minho, Braga, Portugal.
Carlos MagalhãesICVS, University of Minho, Braga, Portugal.
Bing ChenDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, USA.
Mei ChenDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, USA.
John KimDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, USA.
Albel SinghSchool of Biosciences and Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
Catarina M FerreiraICVS, University of Minho, Braga, Portugal.
António G CastroICVS, University of Minho, Braga, Portugal.
Egidio TorradoICVS, University of Minho, Braga, Portugal.
William R JacobsDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, USA.
Apoorva Bhatt *School of Biosciences and Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom a.bhatt@bham.ac.uk margarida.saraiva@ibmc.up.pt.
Margarida Saraiva *i3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal a.bhatt@bham.ac.uk margarida.saraiva@ibmc.up.pt.
University of Minho · PTAlbert Einstein College of Medicine · USi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PTUniversity of Birmingham · GBHeart of England NHS Foundation Trust · GB

Funding

Molecular Genetic Analysis of Mycobacterium TuberculosisR37AI026170 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI WILLIAM Robert JACOBS · 2004 to 2026
$7.7M
MOLECULAR GENETIC ANALYSIS OF MYCOBACTERIUM TUBERCULOSISR01AI026170 · NIAID · YESHIVA UNIVERSITY · PI JACOBS, WILLIAM ROBERT · 1989 to 2022
$7.1M
Howard Hughes Medical InstituteMedical Research CouncilNIAID NIH HHS R01 AI026170NIAID NIH HHS R37 AI026170
6 · The paper itself

Abstract

Nonribosomal peptide synthases produce short peptides in a manner that is distinct from classical mRNA-dependent ribosome-mediated translation. The

Indexed as

AnimalsBacterial LoadDisease Models, AnimalGene DeletionGenes, BacterialLungMice, Inbred C57BLMice, SCIDMycobacterium tuberculosisPeptide SynthasesSpleenSurvival AnalysisTuberculosisVirulenceVirulence Factorsnon-ribosomal peptide synthasePeptide SynthasesVirulence Factorsimmune deficiencypathogenesistuberculosisvirulence factors

Identifiers

PMID30381350
PMCPMC6211224
OpenAlexW2898985696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.