Trial reportHaematologica2019
Related peripheral blood stem cell donors experience more severe symptoms and less complete recovery at one year compared to unrelated donors.
Open access · goldAbstract readClinical TrialComparative StudyMulticenter Study
In one paragraph
Trial report in Haematologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- The Impact of Pre-Apheresis Health Related Quality of Life on Peripheral Blood Progenitor Cell Yield and Donor's Health and Outcome: Secondary Analysis of Patient-Reported Outcome Data from the RDSafe and BMT CTN 0201 Clinical Trials.Transplantation and cellular therapy · 2022Trial
- Similarities and Differences Between Allogeneic Hematopoietic Cell and Organ Transplantation and What We Can Learn From Each Other to Guide Global Health Strategy.Clinical transplantation · 2025Review
- Bone marrow donors: experience among adolescents and young adults.Journal of rural medicine : JRM · 2025Article
- Donation-related decision-making among young adult Black and Hispanic members of a hematopoietic stem cell donor registry: A qualitative study.SSM. Qualitative research in health · 2025Article
- Allogeneic Stem Cell Donation.JAMA · 2025Article
- Graft Source Choice.Advances in experimental medicine and biology · 2025Review
- Supportive Care of Hematopoietic Stem Cell Donors.Clinical hematology international · 2024Article
- Hematopoietic stem cell transplantation: an Italian monocentric experience on the health assessment and eligibility of adult-related donors.Frontiers in oncology · 2024Article
- Article
- Severe short-term adverse events in related bone marrow or peripheral blood stem cell donors.International journal of hematology · 2023Article
- Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022Article
- Syngeneic hematopoietic stem cell transplantation for acute myeloid leukemia: a propensity score-matched analysis.Blood cancer journal · 2021Article
- Serious Adverse Events in Related Donors: A Report from the Related Donor Safe Study.Transplantation and cellular therapy · 2021Observational
- Health-Related Quality-of-Life Comparison of Adult Related and Unrelated HSC Donors: An RDSafe Study.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020Article
- Physical and Psychological Discomfort Experienced by Hematopoietic Stem-Cell Donors.International journal of environmental research and public health · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
61 authors at 20 institutions in 1 country.
Michael A PulsipherChildren's Hospital Los Angeles, CA mpulsipher@chla.usc.edu.
Brent R LoganCenter for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI.
Deidre M KieferCenter for International Blood and Marrow Transplant Research, Division of Biostatistics, Minneapolis, MN.
Pintip ChitphakdithaiCenter for International Blood and Marrow Transplant Research, Division of Biostatistics, Minneapolis, MN.
Marcie L RichesUniversity of North Carolina Hospitals, Division of Hematology and Oncology Chapel Hill, NC.
J Douglas RizzoCenter for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI.
Paolo AnderliniDepartment of Stem Cell Transplantation and Cell Transplantation and Cellular Therapy, Division of Cancer Medicine, MD Anderson Cancer Center, Houston, TX.
O'Susan F LeitmanDepartment of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, MD.
Hati KobusingyeCenter for International Blood and Marrow Transplant Research, Division of Biostatistics, Minneapolis, MN.
RaeAnne M BesserCenter for International Blood and Marrow Transplant Research, Division of Biostatistics, Minneapolis, MN.
John P MillerNational Marrow Donor Program/Be The Match, Minneapolis, MN.
Rebecca J DrexlerCenter for International Blood and Marrow Transplant Research, Division of Biostatistics, Minneapolis, MN.
Aly Abdel-MageedDepartment of Pediatrics and Human Development, Helen DeVos Children's Hospital, Grand Rapids, MI.
Ibrahim A AhmedDepartment of Hematology and Oncology, Children's Mercy Hospitals and Clinics, Kansas City, MO.
Luke P AkardIndiana Blood and Marrow Transplantation, Indianapolis, IN.
Andrew S ArtzUniversity of Chicago Hospitals, IL.
Edward D BallUniversity of California, San Diego Medical Center, La Jolla, CA.
Ruthee-Lu BayerNorth Shore University Hospital, Manhasset, NY.
Carolyn BigelowUniversity of Mississippi Medical Center, Jackson, MS.
Brian J BolwellTaussig Cancer Institute, Cleveland Clinic Foundation, OH.
E Randolph BrounJewish Hospital, Cincinnati, OH.
David C DelgadoIndiana University Hospital/Riley Hospital for Children, IN.
Katharine DuckworthWake Forest University Baptist Medical Center, Winston-Salem, NC.
Christopher C DvorakDivision of Pediatric Blood and Marrow Transplantation, University of California San Francisco Benioff Children's Hospital, CA.
Theresa E HahnRoswell Park Cancer Institute, Buffalo, NY.
Ann E HaightAflac Cancer and Blood Disorders Center, Division of Hematology/Oncology-Bone Marrow Pediatric Hematology & Medical Oncology, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA.
Parameswaran N HariDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI.
Brandon M Hayes-LattinDoernbecher Children's Hospital, Oregon Health & Science University, Portland, OR.
David A JacobsohnChildren's National Medical Center, Washington DC.
Ann A JakubowskiMemorial Sloan Kettering Cancer Center - Adult, New York, NY.
Kimberly A KasowPediatric Hematology Oncology Program, Bone Marrow and Stem Cell Transplantation Program, University of North Carolina Healthcare, Chapel Hill, NC.
Hillard M LazarusSeidman Cancer Center-University Hospitals Cleveland Medical Center, OH.
Jane L LiesveldStrong Memorial Hospital - University of Rochester Medical Center, NY.
Michael LinenbergerDivision of Hematology, Fred Hutchinson Cancer Research Center, Seattle, WA.
Mark R LitzowDivision of Hematology, Mayo Clinic Rochester, MN.
Walter LongoUniversity of Wisconsin Hospital and Clinics, Madison, WI.
Margarida Magalhaes-SilvermanBlood and Marrow Transplant Program, University of Iowa Hospitals & Clinics, Iowa City, IA.
John M McCartyVirginia Commonwealth University Massey Cancer Center Bone Marrow Transplant Program, Richmond, VA.
Joseph P McGuirkUniversity of Kansas, Westwood, KS.
Shahram MoriFlorida Hospital Cancer Institute, Florida Center for Cellular Therapy, Orlando, FL.
Vinod ParameswaranAvera McKennan Transplant Institute, Sioux Falls, SD.
Vinod K PrasadDuke Cancer Institute, Duke University Medical Center, Durham, NC.
Scott D RowleyHackensack University Medical Center, Washington DC.
Witold B RybkaPenn State Health Milton S. Hershey Medical Center, PA.
Indira SahdevCohen Children's Medical Center of New York, New Hyde Park, NY.
Jeffrey R SchriberCancer Transplant Institute Honor Health, Scottsdale, AZ.
George B SelbyHCA Health Services of Oklahoma, Inc., University of Oklahoma, Oklahoma City, OK.
Paul J ShaughnessyTexas Transplant Institute, San Antonio, TX.
Shalini ShenoyDivision of Hematology/Oncology, St. Louis Children's Hospital, MO.
Thomas SpitzerMassachusetts General Hospital, Boston, MA.
William T TseAnn & Robert H. Lurie Children's Hospital of Chicago, IL.
Joseph P UbertiKarmanos Cancer Institute, Detroit, MI.
Madhuri VusirikalaDivision of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, TX.
Edmund K WallerEmory University Hospital, Atlanta, GA.
Daniel J WeisdorfUniversity of Minnesota Medical Center, Fairview, Minneapolis, MN.
Gregory A YanikThe University of Michigan, Ann Arbor, MI.
Willis H NavarroCenter for International Blood and Marrow Transplant Research, Division of Biostatistics, Minneapolis, MN.
Mary M HorowitzCenter for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI.
Galen E SwitzerDivision of General Internal Medicine, University of Pittsburgh, PA, USA.
Dennis L ConferCenter for International Blood and Marrow Transplant Research, Division of Biostatistics, Minneapolis, MN.
Bronwen E ShawCenter for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI.
National Marrow Donor Program · USMedical College of Wisconsin · USAtrium Health Wake Forest Baptist · USAvera McKennan Hospital & University Health Center · USChildren's Healthcare of Atlanta · USChildren's Hospital of Los Angeles · USChildren's Mercy Hospital · USChildren's National · USCHRISTUS Transplant Institute · USCleveland Clinic · USCohen Children's Medical Center · USDoernbecher Children's Hospital · USDuke Medical Center · USEmory University Hospital · USFlorida Hospital Cancer Institute · USFred Hutch Cancer Center · USHackensack University Medical Center · USHelen DeVos Children's Hospital · USHonorHealth · USIndiana Cancer Consortium · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MData Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2MBlood and Marrow Transplant Clinical Trials Network DCC- The Medical College of Wisconsin, Inc.U24HL138660 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Steven M. DeVine, Mehdi Hussain Hamadani · 2017 to 2026
$71.4MUsing donor dendritic cells to optimize GvHD and GvL in allogeneic stem cell transplantationR01AI145231 · NIAID · EMORY UNIVERSITY · PI WALLER, EDMUND K · 2020 to 2024
$3.6MRDSafe: A Multi-Institutional Study of HSC Donor Safety and Quality LifeR01HL085707 · NHLBI · UNIVERSITY OF UTAH · PI PULSIPHER, MICHAEL A, SWITZER, GALEN E. · 2009 to 2013
$3.1MUsing donor pDC to optimize GvHD and GvL in allogeneic stem cell transplantationR01CA188523 · NCI · EMORY UNIVERSITY · PI WALLER, EDMUND K · 2014 to 2018
$1.6MUnrelated Donor BMT vs. Immune Suppression for Newly Diagnosed Severe Aplastic Anemia in Children and Young Adults: BMT CTN Core Center Renewal for the Pediatric Blood and Marrow Transplant ConsortiumUG1HL069254 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI KEAN, LESLIE S · 2017 to 2023
$1.3MNCI NIH HHS P30 CA008748NCI NIH HHS R01 CA188523NCI NIH HHS U24 CA076518NHLBI NIH HHS R01 HL085707NHLBI NIH HHS U24 HL138660NHLBI NIH HHS UG1 HL069254NIAID NIH HHS R01 AI145231
Abstract
Unlike unrelated donor registries, transplant centers lack uniform approaches to related donor assessment and deferral. To test whether related donors are at increased risk for donation-related toxicities, we conducted a prospective observational trial of 11,942 related and unrelated donors aged 18-60 years. Bone marrow (BM) was collected at 37 transplant and 78 National Marrow Donor Program centers, and peripheral blood stem cells (PBSC) were collected at 42 transplant and 87 unrelated donor centers in North America. Possible presence of medical comorbidities was verified prior to donation, and standardized pain and toxicity measures were assessed pre-donation, peri-donation, and one year following. Multivariate analyses showed similar experiences for BM collection in related and unrelated donors; however, related stem cell donors had increased risk of moderate [odds ratios (ORs) 1.42;
Indexed as
Living DonorsPeripheral Blood Stem CellsPeripheral Blood Stem Cell TransplantationQuality of LifeUnrelated DonorsAdolescentAdultFemaleHumansMaleMiddle AgedProspective StudiesYoung Adult
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.