ReviewProgress in neuro-psychopharmacology & biological psychiatry2019
Impaired inhibition as an intermediate phenotype for PTSD risk and treatment response.
Review in Progress in neuro-psychopharmacology & biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impaired learning, memory, and extinction in posttraumatic stress disorder: translational meta-analysis of clinical and preclinical studies.Translational psychiatry · 2023Pooled it
- Auditory associative learning drives synaptic responses in tail of the striatum spiny projection neurons.iScience · 2026Article
- Advancing TMS for PTSD - From networks to individuals.Transcranial magnetic stimulation (2024) · 2025Article
- PV - Oligodendrocyte Interactions in the Infralimbic Cortex Promote Extracellular Plasticity after Safety Learning.bioRxiv : the preprint server for biology · 2025Article
- Safety learning induces postsynaptic potentiation of direct pathway spiny projection neurons in the tail of the striatum.bioRxiv : the preprint server for biology · 2025Article
- Odor-enhanced Visual Processing in PTSD.NeuroImage · 2025Article
- Pavlovian safety learning: An integrative theoretical review.Psychonomic bulletin & review · 2025Review
- Event Segmentation Promotes the Reorganization of Emotional Memory.Journal of cognitive neuroscience · 2025Article
- Linking intrinsic brain dysfunction to behavioral outcomes in combat-exposed males with PTSD symptoms.Frontiers in psychiatry · 2025Article
- Inhibitory control impairments underlie associative memory deficits in posttraumatic stress disorder.PloS one · 2025Article
- Executive functioning in posttraumatic stress disorder: Understanding how inhibition, switching, and test modality affect reaction times.Neuropsychology · 2024Article
- Article
- Sex Differences in Response Inhibition-Related Neural Predictors of Posttraumatic Stress Disorder in Civilians With Recent Trauma.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Unconditioned response to a naturally aversive stimulus is associated with sensitized defensive responding and self-reported fearful traits in a PTSD sample.Psychophysiology · 2024Article
- Understanding nightmares after traumatic events in Detroit (UNiTED): prospective associations with interpersonal violence and posttraumatic stress disorder symptoms.European journal of psychotraumatology · 2024Article
- The Neuronal Hypofunction of Subdivisions of the Prefrontal Cortex Shows Differential Effects on Contingency Judgment Learning to Gauge Fear Responses.Neuroscience insights · 2024Article
- Functional connectivity of amygdala subnuclei in PTSD: a narrative review.Molecular psychiatry · 2023Review
- Altered functional connectivity between cortical networks associated with inhibitory control in trauma-exposed females.Psychiatry research. Neuroimaging · 2023Article
- Expanding the canon: An inclusive neurobiology of thalamic and subthalamic fear circuits.Neuropharmacology · 2023Review
- Stress and sex-dependent effects on conditioned inhibition of fear.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Inhibition of fear involves learning and then appropriately responding to safety signals, and has been shown to be impaired in PTSD patients. Response inhibition refers to cognitive control and likely uses the same prefrontal cortex circuits as fear inhibition, and has also been implicated in PTSD. Impaired inhibition can serve as an intermediate phenotype for PTSD and can be measured with neuroimaging and psychophysiological tools. We first review the neurobiological mechanisms of fear and response inhibition. Next, we summarize the functional magnetic resonance imaging (fMRI) and psychophysiological studies using fear and response inhibition paradigms in PTSD patients. Finally, we evaluate the theranostic role of impaired inhibition in PTSD risk and treatment response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.