Evidence map›Paper›PMID 30380942›Full record

Trial reportClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis2018

Association of Cystathionine β-Synthase Gene Polymorphisms With Preeclampsia.

Mercedes Piedad de León Bautista, Mirza Romero-Valdovinos, Beatriz Zavaleta-Villa, Arony Martínez-Flores, Angélica Olivo-Díaz

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Relationships Between HAntioxidants (Basel, Switzerland) · 2025
    Article
  2. Linking homocysteine and ferroptosis in cardiovascular disease: insights and implications.Apoptosis : an international journal on programmed cell death · 2024
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mercedes Piedad de León BautistaMolecular Diagnostic Lab, CENTRAL ADN. Morelia, Michoacán, Mexico.
Mirza Romero-ValdovinosDepartment of Molecular Biology and Histocompatibility, General Hospital "Dr Manuel Gea Gonzalez," Mexico City, Mexico.
Beatriz Zavaleta-VillaDepartment of Molecular Biology and Histocompatibility, General Hospital "Dr Manuel Gea Gonzalez," Mexico City, Mexico.
Arony Martínez-FloresDepartment of Ecology of Pathogens Agents, General Hospital "Dr Manuel Gea Gonzalez," Mexico City, Mexico.
Angélica Olivo-DíazDepartment of Molecular Biology and Histocompatibility, General Hospital "Dr Manuel Gea Gonzalez," Mexico City, Mexico.ORCID http://orcid.org/0000-0003-0492-1504
Hospital General Dr. Manuel Gea Gonzalez · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preeclampsia (PE) is a pregnancy disorder that increases maternal and fetal morbidity and mortality worldwide. High plasma levels of homocysteine (Hcy) are a risk factor for several cardiovascular diseases. Cystathionine β-synthase (CBS) plays an important role in Hcy homeostasis catalyzing the irreversible degradation of Hcy to cystathionine, protecting the endothelium from injury caused by hypoxia. Several mutations and polymorphisms may alter the expression of the

Indexed as

AllelesGenetic Predisposition to DiseaseGenotypePolymorphism, GeneticAdolescentAdultCase-Control StudiesCystathionine beta-SynthaseFemaleHumansMexicoPre-EclampsiaPregnancyCystathionine beta-SynthaseCBSgene polymorphismshypertensionmutationspreeclampsiapregnancy

Identifiers

PMID30380942
PMCPMC6714820
OpenAlexW2899162884

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.