Evidence map›Paper›PMID 30380840›Full record

ArticleChemical research in toxicology2019

Lateral Flow Assessment and Unanticipated Toxicity of Kratom.

Lauren C Smith, Lucy Lin, Candy S Hwang, Bin Zhou, Diane M Kubitz, Huiying Wang, Kim D Janda

Open access · greenAbstract read
In one paragraph

Article in Chemical research in toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lucy Lin
Bin Zhou
Diane M Kubitz
Huiying WangABiox Company, 720 East First Street , Newberg , Oregon 97132 , United States.
Scripps Research Institute · US

Funding

Immunopharmacotherapy for Mitigating Opioid AddictionUH3DA041146 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI JANDA, KIM · 2017 to 2019
$4.4M
NIDA NIH HHS UH3 DA041146
6 · The paper itself

Abstract

The leaves of the Mitragynine speciosia tree (also known as Kratom) have long been chewed, smoked, or brewed into a tea by people in Southeastern Asian countries, such as Malaysia and Thailand. Just this past year, the plant Kratom gained popularity in the United States as a "legal opioid" and scheduling it as a drug of abuse is currently pending. The primary alkaloid found in Kratom is a μ-opioid receptor agonist, mitragynine, whose structure contains a promising scaffold for immunopharmacological use. Although Kratom is regarded as a safe opioid alternative, here we report the LD

Indexed as

AnimalsAntibodies, MonoclonalInjections, IntravenousMiceMitragynaMolecular ConformationPlant ExtractsPlant LeavesSecologanin Tryptamine AlkaloidsSurface Plasmon Resonance7-hydroxymitragynineAntibodies, MonoclonalmitragyninePlant ExtractsSecologanin Tryptamine Alkaloids

Identifiers

PMID30380840
PMCPMC6662923
OpenAlexW2899422827

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.