ReviewInternational journal of molecular sciences2018
Advances in Understanding the Mechanism of Action of the Auxin Permease AUX1.
Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Nitrogen sources modulate auxin transport to fine-tune root system architecture.Plant cell reports · 2026Article
- Dual ubiquitin signalling by SLOMO controls AUX1 activity and turnover during root gravitropism.The EMBO journal · 2026Article
- OsAux1 is required for nutritropism in rice roots.The Plant journal : for cell and molecular biology · 2026Article
- Structural basis of auxin binding and transport byProceedings of the National Academy of Sciences of the United States of America · 2025Article
- What a tangled web it weaves: auxin coordination of stem cell maintenance and flower production.Journal of experimental botany · 2023Article
- Throttling Growth Speed: Evaluation ofPlants (Basel, Switzerland) · 2022Article
- Dynamic Hormone Gradients Regulate Wound-Induced de novo Organ Formation in Tomato Hypocotyl Explants.International journal of molecular sciences · 2021Article
- Integrating the Roles for Cytokinin and Auxin in De Novo Shoot Organogenesis: From Hormone Uptake to Signaling Outputs.International journal of molecular sciences · 2021Review
- Chemical Biology in Auxin Research.Cold Spring Harbor perspectives in biology · 2021Review
- Cytokinin-Controlled Gradient Distribution of Auxin inInternational journal of molecular sciences · 2021Review
- The TOR-Auxin Connection Upstream of Root Hair Growth.Plants (Basel, Switzerland) · 2021Review
- All Roads Lead to Auxin: Post-translational Regulation of Auxin Transport by Multiple Hormonal Pathways.Plant communications · 2020Review
- The Nuts and Bolts of PIN Auxin Efflux Carriers.Frontiers in plant science · 2019Review
- Developmental Roles of AUX1/LAX Auxin Influx Carriers in Plants.Frontiers in plant science · 2019Review
- Mathematical analysis of long-distance polar auxin transport data of pin mutants questions the role of PIN1 as postulated in the chemi-osmotic theory.Physiologia plantarumArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In over 40 years of research on the cellular uptake of auxin it is somewhat chastening that we have elaborated so little on the original kinetic descriptions of auxin uptake by plant cells made by Rubery and Sheldrake in 1974. Every aspect of that seminal work has been investigated in detail, and the uptake activity they measured is now known to be attributed to the AUX1/LAX family of permeases. Recent pharmacological studies have defined the substrate specificity of AUX1, biochemical studies have evaluated its permeability to auxin in plant cell membranes, and rigourous kinetic studies have confirmed the affinity of AUX1 for IAA and synthetic auxins. Advances in genome sequencing have provided a rich resource for informatic analysis of the ancestry of AUX1 and the LAX proteins and, along with models of topology, suggest mechanistic links to families of eukaryotic proton co-transporters for which crystal structures have been presented. The insights gained from all the accumulated research reflect the brilliance of Rubery and Sheldrake's early work, but recent biochemical analyses are starting to advance further our understanding of this vitally important family of auxin transport proteins.
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Registered trials
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