Observational studyNutrients2018
Prospective Association between Total and Specific Dietary Polyphenol Intakes and Cardiovascular Disease Risk in the Nutrinet-Santé French Cohort.
Observational study in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Dietary intakes of anthocyanins and cardiometabolic health: a systematic review and meta-analysis of randomized trials and prospective cohort studies in healthy participants.The American journal of clinical nutrition · 2026Pooled it
- Anthocyanins, Anthocyanin-Rich Berries, and Cardiovascular Risks: Systematic Review and Meta-Analysis of 44 Randomized Controlled Trials and 15 Prospective Cohort Studies.Frontiers in nutrition · 2021Pooled it
- Relation of Different Fruit and Vegetable Sources With Incident Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies.Journal of the American Heart Association · 2020Pooled it
- Dietary intakes of flavan-3-ols and cardiometabolic health: systematic review and meta-analysis of randomized trials and prospective cohort studies.The American journal of clinical nutrition · 2019Pooled it
- Trial
- Complementary Nutritional Improvements of Cereal-Based Products to Reduce Postprandial Glycemic Response.Nutrients · 2023Trial
- The Influence of Tart Cherry (Nutrients · 2021Trial
- Dose-Dependent Increases in Ellagitannin Metabolites as Biomarkers of Intake in Humans Consuming Standardized Black Raspberry Food Products Designed for Clinical Trials.Molecular nutrition & food research · 2020Trial
- Probiotic and Bioactive Compounds in Foods: From Antioxidant Properties to Gut Microbiota Modulation.Molecules (Basel, Switzerland) · 2026Review
- Association between dietary (poly)phenol intake and the ATHLOS Healthy Ageing Scale in the Polish arm of the HAPIEE study.GeroScience · 2025Article
- Review
- Higher Dietary Polyphenol Intake Is Associated With Lower Blood Inflammatory Markers.The Journal of nutrition · 2024Article
- Sirtfood intake in relation to the 10-year risk of major adverse cardiovascular events: a population-based cohort study.Nutrition & metabolism · 2024Article
- Reproducibility and dietary correlates of plasma polyphenols in the JPHC-NEXT Protocol Area study.European journal of clinical nutrition · 2024Article
- The interaction between polyphenol intake and genes (MC4R, Cav-1, and Cry1) related to body homeostasis and cardiometabolic risk factors in overweight and obese women: a cross-sectional study.Frontiers in nutrition · 2024Article
- Association between dietary intake of anthocyanidins and heart failure among American adults: NHANES (2007-2010 and 2017-2018).Frontiers in nutrition · 2023Article
- Incremental monounsaturated to saturated fat ratio and fibre consumption is associated with a reduction in a composite score of modifiable cardiovascular risk factors: Prospective results from the Moli-sani study.European journal of clinical nutrition · 2022Article
- The association between dietary polyphenol intake and cardiometabolic factors in overweight and obese women: a cross-sectional study.BMC endocrine disorders · 2022Article
- Effect of Dietary Phenolic Compounds on Incidence of Cardiovascular Disease in the SUN Project; 10 Years of Follow-Up.Antioxidants (Basel, Switzerland) · 2022Article
- Improved Endurance Running Performance Following Haskap Berry (Nutrients · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundEpidemiological and experimental evidence support a protective effect of dietary polyphenols on chronic diseases, but high quality longitudinal data are needed, including details on categories of polyphenols. Our objective was to investigate the prospective association between total and individual classes and subclasses of dietary polyphenols and the risk of major cardiovascular disease in the NutriNet-Santé cohort.
methodsA total of 84,158 participants, who completed at least three 24 h dietary records, were included between May 2009 and June 2017. Individual polyphenols intakes were obtained by matching food consumption data from the 24 h dietary records with the Phenol-Explorer polyphenol composition database. Multivariable Cox proportional hazards models were used to characterize the associations between dietary polyphenols and the incidence of cardiovascular diseases, comparing tertile T3 vs. T1 of classes and subclasses of polyphenols.
resultsOver a median of 4.9 years of follow-up, 602 major cardiovascular events were diagnosed. Intakes of anthocyanins, catechins, and flavonols were strongly inversely associated with cardiovascular disease risk (anthocyanins: Hazard Ratio (HR)
conclusionsHigher intakes of polyphenols, especially of anthocyanins, catechins, and flavonols, were associated with a statistically significant decreased cardiovascular disease risk.
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