Evidence map›Paper›PMID 30380653›Full record

ArticleMolecules (Basel, Switzerland)2018

Inhibition of Osteoarthritis-Related Molecules by Isomucronulatol 7-

Gwan Ui Hong, Jung-Yun Lee, Hanna Kang, Tae Yang Kim, Jae Yeo Park, Eun Young Hong, Youn Ho Shin, Sung Hoon Jung, Hung-Bae Chang, Young Ho Kim and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. [Ecliptasaponin A ameliorates DSS-induced colitis in mice by suppressing M1 macrophage polarizationNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  4. Frontiers in pharmacology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Cudratricusxanthone O Inhibits HAntioxidants (Basel, Switzerland) · 2020
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Gwan Ui HongLife & Science Research Center, Hyunsung Vital Co. Ltd., Seoul 07255, Korea. gwanuihong@gmail.com.
Jung-Yun LeeDepartment of Food and Nutrition, Hannam University, Daejeon 34054, Korea. seembeeks@hanmail.net.
Hanna KangDepartment of Food and Nutrition, Hannam University, Daejeon 34054, Korea. hanna9506@hanmail.net.
Tae Yang KimDepartment of Food and Nutrition, Hannam University, Daejeon 34054, Korea. xodid5606@naver.com.
Jae Yeo ParkLife & Science Research Center, Hyunsung Vital Co. Ltd., Seoul 07255, Korea. legolas018@naver.com.
Eun Young HongLife & Science Research Center, Hyunsung Vital Co. Ltd., Seoul 07255, Korea. h_medical@naver.com.
Youn Ho ShinLife & Science Research Center, Hyunsung Vital Co. Ltd., Seoul 07255, Korea. dush84@hanmail.net.
Sung Hoon JungLife & Science Research Center, Hyunsung Vital Co. Ltd., Seoul 07255, Korea. jsh62548@naver.com.
Hung-Bae ChangDepartment of Bio Quality Control, Korea Bio Polytechnic, Chungnam 32943, Korea. hbchang@kopo.ac.kr.
Young Ho KimDepartment of Pharmacy, Choongnam National University, Daejeon 34134, Korea. yhk@cnu.ac.kr.
Young-In KwonDepartment of Food and Nutrition, Hannam University, Daejeon 34054, Korea. youngk@hnu.kr.ORCID 0000-0002-8069-8212
Jai Youl RoLife & Science Research Center, Hyunsung Vital Co. Ltd., Seoul 07255, Korea. jyro426@skku.edu.
Hannam University · KRChungnam National University · KRKorea Bio Polytechnic College · KRSungkyunkwan University · KR

Funding

Hannam University 2018A122
6 · The paper itself

Abstract

Osteoarthritis (OA) is the common form of arthritis and is characterized by disability and cartilage degradation. Although natural product extracts have been reported to have anti-osteoarthritic effects, the potential bioactivity of Ryupunghwan (RPH), a traditional Korean medicinal botanical formula that contains

Indexed as

Anti-Inflammatory Agents, Non-SteroidalBone NeoplasmsCell Line, TumorChondrosarcomaGlucosidesHumansInterleukin-1betaMatrix Metalloproteinase 13OsteoarthritisPlant PreparationsSaponinsAnti-Inflammatory Agents, Non-Steroidalecliptasaponin AGlucosidesInterleukin-1betaMatrix Metalloproteinase 13MMP13 protein, humanPlant PreparationsSaponinschondrosarcoma cellsecliptasaponin AIL-1βisomucronulatol 7-O-β-d-glucosideosteoarthritisRyupunghwan (natural product mixture)

Identifiers

PMID30380653
PMCPMC6278319
OpenAlexW2899193803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.