ArticleNeuroImage. Clinical2018
Methamphetamine dependence with and without psychotic symptoms: A multi-modal brain imaging study.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Cortical Complexity Alterations in Methamphetamine, Cannabis, and Opioid Users: An EEG-Based Analysis.Journal of biomedical physics & engineering · 2026Article
- Assessment of resting cerebral perfusion between methamphetamine-associated psychosis and schizophrenia through arterial spin labeling MRI.European archives of psychiatry and clinical neuroscience · 2025Article
- Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans: an overview of recent findings.Neural regeneration research · 2024Article
- Evaluation of Drug Abuse on Brain Function using Power Spectrum Analysis of Electroencephalogram Signals in Methamphetamine, Opioid, Cannabis, and Multi-Drug Abuser Groups.Journal of biomedical physics & engineering · 2023Article
- Comparing Cognitive Functions in Patients with Schizophrenia and Methamphetamine-Induced Psychosis with Healthy Controls.Addiction & health · 2022Article
- Contrasting dose-dependent effects of acute intravenous methamphetamine on lateral hypothalamic extracellular glucose dynamics in male and female rats.Journal of neurophysiology · 2022Article
- Article
- Goofballing of Opioid and Methamphetamine: The Science Behind the Deadly Cocktail.Frontiers in pharmacology · 2022Review
- Abnormal resting-state functional connectome in methamphetamine-dependent patients and its application in machine-learning-based classification.Frontiers in neuroscience · 2022Article
- Neuroimaging the Neuropathogenesis of HIV.Current HIV/AIDS reports · 2021Review
- Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users.Scientific reports · 2021Article
- Sex Differences in Substance Use Disorders: A Neurobiological Perspective.Frontiers in global women's health · 2021Review
- Differences in the amplitude of low-frequency fluctuation between methamphetamine and heroin use disorder individuals: A resting-state fMRI study.Brain and behavior · 2020Article
- A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia.Psychopharmacology · 2019Observational
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMethamphetamine dependence can lead to psychotic symptoms which may be mediated by frontal, striatal, limbic, and thalamic regions. There are few neuroimaging data that allow comparison of individuals with methamphetamine dependence who do, and do not, have psychosis. Two complementary imaging techniques were employed to investigate neurocircuitry associated with methamphetamine dependence with and without psychotic symptoms.
methodsThree groups of participants were recruited: methamphetamine dependent (MAA) (N = 11), methamphetamine dependent with psychotic symptoms (MAP) (N = 14), and controls (N = 14). Resting brain glucose metabolism was measured using [
resultsMethamphetamine abusers (MAA and MAP groups) had decreased glucose metabolism compared to healthy controls in the left insula, left precentral gyrus, and the anterior cingulate cortex. Compared to MAA participants, MAP participants had 1) decreased glucose metabolism in the left precentral gyrus and the left inferior frontal gyrus and 2) increased glucose metabolism in the putamen and pallidum. MAP participants also had increased cerebral perfusion in the right putamen and right pallidum compared to MAA.
conclusionFindings support the involvement of frontal, striatal, and limbic regions in methamphetamine dependence. Furthermore, they indicate that glucose metabolism and cerebral perfusion in these regions are disrupted in methamphetamine dependent individuals with psychotic symptoms.
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