Evidence map›Paper›PMID 30380425›Full record

ArticleCell reports2018

Recording Neural Activity in Unrestrained Animals with Three-Dimensional Tracking Two-Photon Microscopy.

Doycho Karagyozov, Mirna Mihovilovic Skanata, Amanda Lesar, Marc Gershow

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Multiple Scales of Coordination along the Body Axis duringThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Review
  4. CRASH2p: Closed-loop Two Photon Imaging in a Freely Moving Animal.bioRxiv : the preprint server for biology · 2024
    Article
  5. Article
  6. Review
  7. The connectome of an insect brain.Science (New York, N.Y.) · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Quantitative Pulmonary Neutrophil Dynamics Using Computer-Vision Stabilized Intravital Imaging.American journal of respiratory cell and molecular biology · 2022
    Article
  14. Article
  15. Article
  16. Lighting Up CaCells · 2021
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Doycho KaragyozovDepartment of Physics, New York University, New York, NY, USA.
Mirna Mihovilovic SkanataDepartment of Physics, New York University, New York, NY, USA.
Amanda LesarDepartment of Physics, New York University, New York, NY, USA.
Marc GershowDepartment of Physics, New York University, New York, NY, USA; Center for Neural Science, New York University, New York, NY, USA; Neuroscience Institute, New York University, New York, NY, USA. Electronic address: marc.gershow@nyu.edu.
New York University · USNeurosciences Institute · US

Funding

Dissecting Olfactory Decision Making Using Optical NeurophysiologyDP2EB022359 · NIBIB · NEW YORK UNIVERSITY · PI GERSHOW, MARC HERMAN · 2015 to 2015
$2.4M
NIBIB NIH HHS DP2 EB022359
6 · The paper itself

Abstract

Optical recordings of neural activity in behaving animals can reveal the neural correlates of decision making, but brain motion, which often accompanies behavior, compromises these measurements. Two-photon point-scanning microscopy is especially sensitive to motion artifacts, and two-photon recording of activity has required rigid coupling between the brain and microscope. We developed a two-photon tracking microscope with extremely low-latency (360 μs) feedback implemented in hardware. This microscope can maintain continuous focus on neurons moving with velocities of 3 mm/s and accelerations of 1 m/s

Indexed as

Imaging, Three-DimensionalMicroscopy, Fluorescence, MultiphotonRestraint, PhysicalAnimalsArtifactsBehavior, AnimalCalciumDrosophila melanogasterInterneuronsLarvaLightLocomotionMotionMotor NeuronsVisual PathwaysCalciumcalcium imagingDrosophila, 3D tracking systemfreely behaving larval Drosophilaneurosciencetracking microscopytwo photon microscopyvoltage imaging

Identifiers

PMID30380425
PMCPMC6287944
OpenAlexW2899255966

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.