Evidence map›Paper›PMID 30380366›Full record

ArticlePathogens and global health2018

Elucidating the survival and response of carbapenem resistant Klebsiella pneumoniae after exposure to imipenem at sub-lethal concentrations.

Ye Mun Low, Chun Wie Chong, Ivan Kok Seng Yap, Lay Ching Chai, Stuart C Clarke, Sasheela Ponnampalavanar, Kartini Abdul Jabar, Mohd Yasim Md Yusof, Cindy Shuan Ju Teh

Open access · greenAbstract read
In one paragraph

Article in Pathogens and global health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Progressive Sub-MIC Exposure ofAntibiotics (Basel, Switzerland) · 2023
    Article
  4. Characterization of two multidrug-resistantFrontiers in microbiology · 2023
    Article
  5. Article
  6. Review
  7. Article
  8. Ceftazidime-avibactam based combinations against carbapenemase producingComputational and structural biotechnology journal · 2022
    Article
  9. Review
  10. Transcriptome-based design of antisense inhibitors potentiates carbapenem efficacy in CREProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Ye Mun Lowa Department of Medical Microbiology, Faculty of Medicine , University of Malaya , Kuala Lumpur , Malaysia.
Chun Wie Chongb Department of Life Sciences, School of Pharmacy , International Medical University , Bukit Jalil , Kuala Lumpur , Malaysia.
Ivan Kok Seng Yapd Clinical Research Centre, Sarawak General Hospital , Jalan Hospital , Kuching , Malaysia.ORCID 0000-0002-7523-5352
Lay Ching Chaie Institute of Biological Sciences , University of Malaya , Kuala Lumpur , Malaysia.
Stuart C Clarkef Faculty of Medicine and Institute for Life Sciences and Global Health Research Institute , University of Southampton , Southampton , UK.
Sasheela Ponnampalavanari Department of Medicine, Faculty of Medicine , University of Malaya , Kuala Lumpur , Malaysia.
Kartini Abdul Jabara Department of Medical Microbiology, Faculty of Medicine , University of Malaya , Kuala Lumpur , Malaysia.
Mohd Yasim Md Yusofa Department of Medical Microbiology, Faculty of Medicine , University of Malaya , Kuala Lumpur , Malaysia.
Cindy Shuan Ju Teha Department of Medical Microbiology, Faculty of Medicine , University of Malaya , Kuala Lumpur , Malaysia.
University Malaya Medical Centre · MYUniversity of Malaya · MYInstitute for Medical Research · MYNIHR Southampton Biomedical Research Centre · GBSarawak General Hospital · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing prevalence of antibiotic resistant pathogens poses a serious threat to global health. However, less emphasis has been placed to co-relate the gene expression and metabolism of antibiotic resistant pathogens. This study aims to elucidate gene expression and variations in metabolism of multidrug resistant Klebsiella pneumoniae after exposure to antibiotics. Phenotypic responses of three genotypically distinct carbapenem resistant Klebsiella pneumoniae (CRKP) strains untreated and treated with sub-lethal concentrations of imipenem were investigated via phenotype microarrays (PM). The gene expression and metabolism of the strain harboring bla

Indexed as

Anti-Bacterial AgentsBacterial ProteinsBacterial Typing TechniquesDrug Resistance, BacterialHumansImipenemKlebsiella InfectionsKlebsiella pneumoniaeMicrobial Sensitivity TestsPhenotypeAnti-Bacterial AgentsBacterial ProteinsImipenem1H NMRantibiotic resistanceCarbapenem resistant Klebsiella pneumoniaephenotype microarraysRNA-Seq

Identifiers

PMID30380366
PMCPMC6300736
OpenAlexW2898618941

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.