Evidence map›Paper›PMID 30379940›Full record

ArticlePloS one2018

Delayed first active-phase meal, a breakfast-skipping model, led to increased body weight and shifted the circadian oscillation of the hepatic clock and lipid metabolism-related genes in rats fed a high-fat diet.

Hatsumi Shimizu, Fumiaki Hanzawa, Daeun Kim, Shumin Sun, Thomas Laurent, Miki Umeki, Saiko Ikeda, Satoshi Mochizuki, Hiroaki Oda

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

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  7. Liver clock: Malalignment and entrainment therapeutics.World journal of gastrointestinal pharmacology and therapeutics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hatsumi ShimizuLaboratory of Nutritional Biochemistry, Nagoya University, Nagoya, Japan.
Fumiaki HanzawaDepartment of Nutritional Sciences, Nagoya University of Arts and Sciences, Nisshin, Japan.
Daeun KimLaboratory of Nutritional Biochemistry, Nagoya University, Nagoya, Japan.
Shumin SunLaboratory of Nutritional Biochemistry, Nagoya University, Nagoya, Japan.
Thomas LaurentInstitute of Innovation for Future Society, Nagoya University, Nagoya, Japan.
Miki UmekiFaculty of Education, Oita University, Oita, Japan.
Saiko IkedaDepartment of Nutritional Sciences, Nagoya University of Arts and Sciences, Nisshin, Japan.
Satoshi MochizukiFaculty of Education, Oita University, Oita, Japan.
Hiroaki OdaLaboratory of Nutritional Biochemistry, Nagoya University, Nagoya, Japan.ORCID 0000-0001-9129-9076
Nagoya University · JPNagoya University of Arts and Sciences · JPOita University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The circadian clock is closely related to human health, such as metabolic syndrome and cardiovascular disease. Our previous study revealed that irregular feeding induced abnormal lipid metabolism with disruption of the hepatic circadian clock. We hypothesized that breakfast skipping induces lipid abnormalities, such as adiposity, by altering the hepatic circadian oscillation of clock and lipid metabolism-related genes. Here, we established a delayed first active-phase meal (DFAM) protocol as a breakfast-skipping model. Briefly, rats were fed a high-fat diet during zeitgeber time (ZT) 12-24 in a control group and ZT 16-4 in the DFAM group. The DFAM group showed increased body weight gain and perirenal adipose tissue weight without a change in total food intake. The circadian oscillations of hepatic clock and de novo fatty acid synthesis genes were delayed by 2-4 h because of DFAM. The peaks of serum insulin, a synchronizer for the liver clock, bile acids, and non-esterified fatty acid (NEFA) were delayed by 4-6 h because of DFAM. Moreover, DFAM delayed the surge in body temperature by 4 h and may have contributed to the increase in body weight gain and adipose tissue weight because of decreased energy expenditure. These data indicated a potential molecular mechanism by which breakfast skipping induces abnormal lipid metabolism, which is related to the altered circadian oscillation of hepatic gene expression. The results also suggested that the delayed peaks of serum NEFA, bile acids, and insulin entrain the circadian rhythm of hepatic clock and lipid metabolism-related genes.

Indexed as

Diet, High-FatMealsAdiposityAnimalsBile Acids and SaltsBlood GlucoseBody WeightCircadian RhythmFatty Acids, NonesterifiedFeeding BehaviorInsulinLipid MetabolismLiverMaleRatsRats, WistarBile Acids and SaltsBlood GlucoseFatty Acids, NonesterifiedInsulin

Identifiers

PMID30379940
PMCPMC6209334
OpenAlexW2898756839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.