Evidence map›Paper›PMID 30379906›Full record

ArticlePloS one2018

Genetic association study of dyslexia and ADHD candidate genes in a Spanish cohort: Implications of comorbid samples.

Mirian Sánchez-Morán, Juan Andrés Hernández, Jon Andoni Duñabeitia, Adelina Estévez, Laura Bárcena, Aintzane González-Lahera, María Teresa Bajo, Luis J Fuentes, Ana M Aransay, Manuel Carreiras

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Genetic Variants Linked to Dyslexia Co-Morbid ADHD: A Case Study of a Pakistani Outpatient.Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Mirian Sánchez-MoránBCBL-Basque Center on Cognition Brain and Language, Donostia-San Sebastian, Gipuzkoa, Spain.
Juan Andrés HernándezUniversidad de La Laguna, Tenerife, Spain.
Jon Andoni DuñabeitiaBCBL-Basque Center on Cognition Brain and Language, Donostia-San Sebastian, Gipuzkoa, Spain.ORCID 0000-0002-3312-8559
Adelina EstévezUniversidad de La Laguna, Tenerife, Spain.
Laura BárcenaCIC bioGUNE, Derio, Bizkaia, Spain.
Aintzane González-LaheraCIC bioGUNE, Derio, Bizkaia, Spain.
María Teresa BajoResearch Center for Brain, Mind & Behavior, Universidad de Granada, Granada, Spain.
Luis J FuentesUniversidad de Murcia, Murcia, Spain.
Ana M AransayCIC bioGUNE, Derio, Bizkaia, Spain.ORCID 0000-0002-8271-612X
Manuel CarreirasBCBL-Basque Center on Cognition Brain and Language, Donostia-San Sebastian, Gipuzkoa, Spain.ORCID 0000-0001-6726-7613
Basque Center on Cognition, Brain and Language · ESInstituto de Salud Carlos III · ESUniversidad de La Laguna · ESCIC bioGUNE · ESIkerbasque · ESUniversidad de Granada · ESUniversidad de Murcia · ES

Funding

European Research Council 295362
6 · The paper itself

Abstract

Dyslexia and attention deficit hyperactivity disorder (ADHD) are two complex neuro-behaviorally disorders that co-occur more often than expected, so that reading disability has been linked to inattention symptoms. We examined 4 SNPs located on genes previously associated to dyslexia (KIAA0319, DCDC2, DYX1C1 and FOXP2) and 3 SNPs within genes related to ADHD (COMT, MAOA and DBH) in a cohort of Spanish children (N = 2078) that met the criteria of having one, both or none of these disorders (dyslexia and ADHD). We used a case-control approach comparing different groups of samples based on each individual diagnosis. In addition, we also performed a quantitative trait analysis with psychometric measures on the general population (N = 3357). The results indicated that the significance values for some markers change depending on the phenotypic groups compared and/or when considering pair-wise marker interactions. Furthermore, our quantitative trait study showed significant genetic associations with specific cognitive processes. These outcomes advocate the importance of establishing rigorous and homogeneous criteria for the diagnosis of cognitive disorders, as well as the relevance of considering cognitive endophenotypes.

Indexed as

Genetic Association StudiesAttention Deficit Disorder with HyperactivityChildCognitionCohort StudiesComorbidityDyslexiaFemaleGenotyping TechniquesHumansMalePolymorphism, Single NucleotideSpain

Identifiers

PMID30379906
PMCPMC6209299
OpenAlexW2899023340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.