ArticlePLoS biology2018
EGFR signaling coordinates patterning with cell survival during Drosophila epidermal development.
Article in PLoS biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Glia generate distinct visual processing centres by locally inhibiting ERK activity in an optic lobe neuroepithelium.bioRxiv : the preprint server for biology · 2026Article
- Reduction of endocytosis and EGFR signaling is associated with the switch from isolated to clustered apoptosis during epithelial tissue remodeling in Drosophila.PLoS biology · 2024Article
- Wnt signaling modulates the response to DNA damage in the Drosophila wing imaginal disc by regulating the EGFR pathway.PLoS biology · 2024Article
- Patterned apoptosis has an instructive role for local growth and tissue shape regulation in a fast-growing epithelium.Current biology : CB · 2024Article
- Epidermal growth factor receptor signaling protects epithelia from morphogenetic instability and tissue damage in Drosophila.Development (Cambridge, England) · 2023Article
- A role for Flower and cell death in controlling morphogen gradient scaling.Nature cell biology · 2022Article
- Avalanches during epithelial tissue growth; Uniform Growth and a drosophila eye disc model.PLoS computational biology · 2022Article
- Article
- Time and space in segmentation.Interface focus · 2021Article
- Regulation of size and scale in vertebrate spinal cord development.Wiley interdisciplinary reviews. Developmental biology · 2021Review
- Natural variation in the regulation of neurodevelopmental genes modifies flight performance in Drosophila.PLoS genetics · 2021Article
- JNK Mediates Differentiation, Cell Polarity and Apoptosis During Amphioxus Development by Regulating Actin Cytoskeleton Dynamics and ERK Signalling.Frontiers in cell and developmental biology · 2021Article
- Histone deacetylase (Rpd3) regulatesOpen biology · 2020Article
- The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning.eLife · 2019Article
- Competition for Space Induces Cell Elimination through Compaction-Driven ERK Downregulation.Current biology : CB · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
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Abstract
Extensive apoptosis is often seen in patterning mutants, suggesting that tissues can detect and eliminate potentially harmful mis-specified cells. Here, we show that the pattern of apoptosis in the embryonic epidermis of Drosophila is not a response to fate mis-specification but can instead be explained by the limiting availability of prosurvival signaling molecules released from locations determined by patterning information. In wild-type embryos, the segmentation cascade elicits the segmental production of several epidermal growth factor receptor (EGFR) ligands, including the transforming growth factor Spitz (TGFα), and the neuregulin, Vein. This leads to an undulating pattern of signaling activity, which prevents expression of the proapoptotic gene head involution defective (hid) throughout the epidermis. In segmentation mutants, where specific peaks of EGFR ligands fail to form, gaps in signaling activity appear, leading to coincident hid up-regulation and subsequent cell death. These data provide a mechanistic understanding of how cell survival, and thus appropriate tissue size, is made contingent on correct patterning.
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