ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2018
Three-Year Outcomes With Hypofractionated Versus Conventionally Fractionated Whole-Breast Irradiation: Results of a Randomized, Noninferiority Clinical Trial.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07020780 (Five Fractions Ultrahypofractionated Whole Breast Radiotherapy and Simultaneous Integrated Boost to the Tumor Bed, for Breast Cancer Patients With Unfavorable Characteristics), which is not on this map. Cited by 40 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 5 pooled it
2.1field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Five Fractions Ultrahypofractionated Whole Breast Radiotherapy and Simultaneous Integrated Boost to the Tumor Bed, for Breast Cancer Patients With Unfavorable Characteristics
Who cites it
40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Pooled it
- Efficacy and cosmetic outcomes of radiotherapy modalities in early-stage breast cancer: a systematic review and network meta-analysis.Frontiers in oncology · 2026Pooled it
- Randomised controlled trials on radiation dose fractionation in breast cancer: systematic review and meta-analysis with emphasis on side effects and cosmesis.BMJ (Clinical research ed.) · 2024Pooled it
- Efficacy and safety analysis of hypofractionated and conventional fractionated radiotherapy in postoperative breast cancer patients.BMC cancer · 2024Pooled it
- Comparing Hypofractionated With Conventional Fractionated Radiotherapy After Breast-Conserving Surgery for Early Breast Cancer: A Meta-Analysis of Randomized Controlled Trials.Frontiers in oncology · 2021Pooled it
- Ultrahypofractionated partial breast irradiation following oncoplastic surgery: secondary analysis of a phase II trial.Radiation oncology (London, England) · 2025Trial
- One versus three weeks hypofractionated whole breast radiotherapy for early breast cancer treatment: the FAST-Forward phase III RCT.Health technology assessment (Winchester, England) · 2023Trial
- Optimizing Preventive Adjuvant Linac-Based (OPAL) Radiation: A Phase 2 Trial of Daily Partial Breast Irradiation.International journal of radiation oncology, biology, physics · 2023Trial
- Hypofractionation with simultaneous integrated boost after breast-conserving surgery: Long term results of two phase-II trials.Breast (Edinburgh, Scotland) · 2022Trial
- Five-Year Longitudinal Analysis of Patient-Reported Outcomes and Cosmesis in a Randomized Trial of Conventionally Fractionated Versus Hypofractionated Whole-Breast Irradiation.International journal of radiation oncology, biology, physics · 2021Trial
- Adjuvant hypofractionated radiotherapy with simultaneous integrated boost after breast-conserving surgery: results of a prospective trial.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021Trial
- Acute toxicity of normofractionated intensity modulated radiotherapy with simultaneous integrated boost compared to three-dimensional conformal radiotherapy with sequential boost in the adjuvant treatment of breast cancer.Radiation oncology (London, England) · 2020Trial
- Boost Approaches in Patients Undergoing Postoperative Radiotherapy.Journal of surgical oncology · 2026Review
- The impact of positioning errors on the dose distribution of hypofractionated radiotherapy for left-sided radical breast cancer.Frontiers in oncology · 2026Article
- Comparison of simultaneous integrated tumor bed boost and sequential boost during hypofractionated whole-breast irradiation after breast-conserving surgery.Clinical and translational radiation oncology · 2025Article
- Review
- Mepitel® film versus standard care for the prevention of skin toxicity in breast cancer patients treated with adjuvant radiotherapy: A randomized controlled trial.Clinical and translational radiation oncology · 2025Article
- De-escalation of regional nodal irradiation fields in pT1-2N1 breast cancer patients after breast conserving surgery: retrospective real-world clinical experience.Frontiers in oncology · 2025Article
- Impact of the COVID-19 Pandemic on Hypofractionated Radiation Therapy Use for Breast Cancer in Japan: A Nationwide Study.Advances in radiation oncology · 2024Article
- Interplay of Oncoplastic Reconstruction and Adjuvant Radiation Therapy in Breast Cancer.Advances in radiation oncology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors.
Simona F ShaitelmanSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Xiudong LeiSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Alastair ThompsonSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Pamela SchlembachSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Elizabeth S BloomSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Isidora Y ArzuSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Daniel BuchholzSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Gregory ChronowskiSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Tomas DvorakSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Emily GradeSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Karen HoffmanSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
George PerkinsSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Valerie K ReedSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Shalin J ShahSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Michael C StauderSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Eric A StromSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Welela TereffeSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Wendy A WoodwardSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Diana N AmayaSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Yu ShenSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Gabriel N HortobagyiSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Kelly K HuntSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Thomas A BuchholzSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Benjamin D SmithSimona F. Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S. Bloom, Isidora Y. Arzu, Gregory Chronowski, Karen Hoffman, George Perkins, Valerie K. Reed, Shalin J. Shah, Michael C. Stauder, Eric A. Strom, Welela Tereffe, Wendy A. Woodward, Diana N. Amaya, Yu Shen, Gabriel N. Hortobagyi, Kelly K. Hunt, and Benjamin D. Smith, University of Texas MD Anderson Cancer Center, Houston, TX; Daniel Buchholz and Tomas Dvorak, Orlando Health UF Health Cancer Center, Orlando, FL; Emily Grade, Banner MD Anderson Cancer Center, Gilbert AZ; and Thomas A. Buchholz, Scripps MD Anderson Cancer Center, La Jolla, CA.
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8MTechnology Diffusion in Cancer: Geographic Variations, Facilitators, Outcomes, and CostsR01CA207216 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SHIH, YA-CHEN TINA · 2016 to 2020
$1.6MNCI NIH HHS P30 CA016672NCI NIH HHS R01 CA207216
Abstract
purposeThe adoption of hypofractionated whole-breast irradiation (HF-WBI) remains low, in part because of concerns regarding its safety when used with a tumor bed boost or in patients who have received chemotherapy or have large breast size. To address this, we conducted a randomized, multicenter trial to compare conventionally fractionated whole-breast irradiation (CF-WBI; 50 Gy/25 fx + 10 to 14 Gy/5 to 7 fx) with HF-WBI (42.56 Gy/16 fx + 10 to 12.5 Gy/4 to 5 fx). PATIENTS AND
methodsFrom 2011 to 2014, 287 women with stage 0 to II breast cancer were randomly assigned to CF-WBI or HF-WBI, stratified by chemotherapy, margin status, cosmesis, and breast size. The trial was designed to test the hypothesis that HF-WBI is not inferior to CF-WBI with regard to the proportion of patients with adverse cosmetic outcome 3 years after radiation, assessed using the Breast Cancer Treatment Outcomes Scale. Secondary outcomes included photographically assessed cosmesis scored by a three-physician panel and local recurrence-free survival. Analyses were intention to treat.
resultsA total of 286 patients received the protocol-specified radiation dose, 30% received chemotherapy, and 36.9% had large breast size. Baseline characteristics were well balanced. Median follow-up was 4.1 years. Three-year adverse cosmetic outcome was 5.4% lower with HF-WBI ( P
conclusionThree years after WBI followed by a tumor bed boost, outcomes with hypofractionation and conventional fractionation are similar. Tumor bed boost, chemotherapy, and larger breast size do not seem to be strong contraindications to HF-WBI.
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NCT07020780ClinicalTrials.gov
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