Evidence map›Paper›PMID 30379558›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2018

Dehydroepiandrosterone inhibits I

Rikuo Ochi, Sukrutha Chettimada, Igor Kizub, Sachin A Gupte

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Acquired Glucose-6-Phosphate Dehydrogenase Deficiency.Journal of clinical medicine · 2022
    Review
  4. Terbinafine prevents colorectal cancer growth by inducing dNTP starvation and reducing immune suppression.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Article
  5. Menopause, androgens, and cardiovascular ageing: a narrative review.Therapeutic advances in endocrinology and metabolism · 2022
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rikuo OchiDepartment of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama , Mobile, Alabama.ORCID 0000-0002-8790-4496
Sukrutha ChettimadaDepartment of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama , Mobile, Alabama.
Igor KizubDepartment of Pharmacology, New York Medical College, Valhalla, New York.
Sachin A GupteDepartment of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama , Mobile, Alabama.
New York Medical College · USHarvard University · US

Funding

Regulation of Vascular Smooth Muscle Cell Phenotype by a Novel Isoform of Glucose-6-Phosphate DehydrogenaseR01HL132574 · NHLBI · NEW YORK MEDICAL COLLEGE · PI GUPTE, SACHIN A, MIANO, JOSEPH M · 2017 to 2020
$2.5M
Regulation of Vascular Smooth Muscle Calcium by NADPH RedoxR01HL085352 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI GUPTE, SACHIN A · 2008 to 2012
$1.9M
NHLBI NIH HHS R01 HL085352NHLBI NIH HHS R01 HL132574
6 · The paper itself

Abstract

Dehydroepiandrosterone (DHEA) is an adrenal steroid hormone, which has the highest serum concentration among steroid hormones with DHEA sulfate (DHEAS). DHEA possesses an inhibitory action on glucose-6-phosphate dehydrogenase (G6PD), the first pentose-phosphate pathway enzyme that reduces NADP

Indexed as

Action PotentialsAnimalsArteriesCalcium Channels, L-TypeCells, CulturedDehydroepiandrosteroneFemaleHormonesMyocytes, Smooth MuscleRatsRats, WistarCalcium Channels, L-TypeDehydroepiandrosteroneHormonesCa channel blockerdehydroepiandrosteroneglucose-6-phosphate dehydrogenaseL-type Ca currentwindow current

Identifiers

PMID30379558
PMCPMC6336967
OpenAlexW2899037777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.