ArticleThe journal of nutrition, health & aging2018
Vitamin D Binding Protein and Vitamin D Levels in Multi-Ethnic Population.
Article in The journal of nutrition, health & aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Association between serum vitamin D level and Graves' disease: a systematic review and meta-analysis.Nutrition journal · 2024Pooled it
- Prevalence of Vitamin D Hypovitaminosis in Croatia: A Cross-Sectional Study Based on Routine Clinical Examinations.Nutrients · 2025Article
- Association of Preoperative Serum 25-Hydroxyvitamin D with Longitudinal Body Mass Index After Bariatric Surgery-A Mediation Effect of Serum Albumin.Obesity surgery · 2025Article
- Structural diversification of vitamin D using microbial biotransformations.Applied microbiology and biotechnology · 2024Review
- 25-hydroxyvitamin D level is associated with greater grip strength across adult life span: a population-based cohort study.Endocrine connections · 2023Article
- Article
- Association between dentition and frailty and cognitive function in community-dwelling older adults.BMC geriatrics · 2022Article
- Editorial: Old Bones.The journal of nutrition, health & aging · 2020Article
- Prevalence of Metabolic Syndrome and Association with Grip Strength in Older Adults: Findings from the HOPE Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Editorial: COVID-19 - The Long Road to Recovery.The journal of nutrition, health & aging · 2020Article
- Editorial: Vitamin D: Does the Emperor Have No Clothes?The journal of nutrition, health & aging · 2019Article
- Editorial: Screening for Sarcopenia.The journal of nutrition, health & aging · 2019Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLow levels of 25-hydroxyvitamin D (25(OH)D) has been associated with many negative health outcomes including falls and fractures. 25(OH)D is largely bound to vitamin D binding protein (VDBP). There is increasing evidence that free or bioavailable 25(OH)D may be a better measure of vitamin D deficiency.
objectiveTo determine the prevalence of 25(OH)D deficiency and VDBP levels in multi-ethnic population, and its impact on muscle strength. DESIGN AND
methodsCross-sectional study of older adults in Western region of Singapore. 295 participants from three ethnic groups were selected from the Healthy Older People Everyday (HOPE) cohort for measurements of total 25(OH)D and VDBP levels. Total 25(OH)D, VDBP, frailty status, Timed-Up-and-Go (TUG) and grip strength (GS) were assessed. Albumin, free and bioavailable 25(OH)D were only available for 256 participants.
results53% of Malay and 55% of Indians were deficient in 25(OH)D compared with 18.2% of ethnic Chinese participants. Chinese also had higher total 25(OH)D concentrations with a mean of 29.1 ug/l, (p = <0.001). Chinese had the lowest level of VDBP (169.6ug/ml) followed by Malay (188.8 ug/ml) and Indian having the highest (220.1 ug/ml). Calculated bioavailable and free 25(OH)D levels were significantly higher in Chinese, followed by Malays and Indians, which also correlated with better grip strength measures amongst the Chinese.
conclusionThe Malays and Indians had overall lower free, bioavailable and total 25(OH)D compared with ethnic Chinese. Chinese ethnic group also had the lowest VDBP and better overall grip strength.
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Registered trials
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