ArticleJournal of cachexia, sarcopenia and muscle2019
Host phenotype is associated with reduced survival independent of tumour biology in patients with colorectal liver metastases.
Article in Journal of cachexia, sarcopenia and muscle, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05899205 (Patient Recorded Indexing Measurements), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Patient Recorded Indexing Measurements
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- The prognostic significance of histopathological growth patterns in liver metastases undergoing surgery: a systematic review and meta-analysis.Clinical & experimental metastasis · 2025Pooled it
- Adiposity and cancer survival: a systematic review and meta-analysis.Cancer causes & control : CCC · 2022Pooled it
- Body Composition Is a Predictor for Postoperative Complications After Gastrectomy for Gastric Cancer: a Prospective Side Study of the LOGICA Trial.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Trial
- Multinomial Classification Certainty: a new uncertainty metric for multinomial outcome prediction.Progress in artificial intelligence · 2026Article
- Article
- Beyond the tumor: towards a cachexia-based host phenotype through body composition analysis in patients with resectable lung cancer.Translational lung cancer research · 2025Review
- C-reactive protein and digestive pathologies: A narrative review for daily clinical use.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Review
- External validation of a deep learning model for automatic segmentation of skeletal muscle and adipose tissue on abdominal CT images.The British journal of radiology · 2024Article
- Muscle loss during cancer therapy is associated with poor outcomes in advanced ovarian cancer.Journal of the National Cancer Institute. Monographs · 2023Article
- Fat signal fraction assessed with MRI predicts hepatic recurrence following hepatic resection for colorectal liver metastases.Langenbeck's archives of surgery · 2022Article
- Imaging based body composition profiling and outcomes after oncologic liver surgery.Frontiers in oncology · 2022Review
- Prognostic Significance of Preoperative Sarcopenia in Patients With Gastric Cancer Liver Metastases Receiving Hepatectomy.Frontiers in nutrition · 2022Article
- Functional Outcomes and Their Association With Physical Performance in Mechanically Ventilated Coronavirus Disease 2019 Survivors at 3 Months Following Hospital Discharge: A Cohort Study.Critical care medicine · 2021Observational
- Ectopic fat in liver and skeletal muscle is associated with shorter overall survival in patients with colorectal liver metastases.Journal of cachexia, sarcopenia and muscle · 2021Article
- Review
- Article
- Host phenotype is associated with reduced survival independent of tumour biology in patients with colorectal liver metastases.Journal of cachexia, sarcopenia and muscle · 2019Article
- A tale of two CT studies: the combined impact of multiple human body composition projects in cancer.Journal of cachexia, sarcopenia and muscle · 2019Article
- Cachexia as a common characteristic in multiple chronic disease.Journal of cachexia, sarcopenia and muscle · 2018Article
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Authors and funding
12 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMost prognostic scoring systems for colorectal liver metastases (CRLMs) account for factors related to tumour biology. Little is known about the effects of the host phenotype to the tumour. Our objective was to delineate the relationship of systemic inflammation and body composition features [i.e. low skeletal muscle mass (sarcopenia) and low visceral adipose tissue (VAT)], two well-described host phenotypes in cancer.
methodsClinical data and pre-operative blood samples were collected from 99 patients who underwent resection of CRLM. Pre-operative computed tomography scans were available for 97 patients; body composition was analysed at the L3 level, stratified for sex and age. Clinicopathological variables, serum C-reactive protein (CRP), and various body composition variables were evaluated. Overall survival was evaluated as a function of these same variables in multivariate Cox regression analysis.
resultsSkeletal muscle was significantly correlated with VAT (r = 0.46, P < 0.001). Of patients with sarcopenia, 35 (65%) also had low VAT. C-reactive protein was elevated (≥5 mg/mL) in 42 patients (43.3%). Elevated CRP was more common in patients with sarcopenia (73.8% vs. 51.1%, P = 0.029). The most significant prognostic factors were the coincidence of elevated CRP and adverse body composition features (sarcopenia and/or low VAT; hazard ratio 4.3, 95% confidence interval 1.5-13.0, P = 0.008), as well as Fong clinical prognostic score (hazard ratio 2.9, 95% confidence interval 1.5-5.5, P = 0.002).
conclusionsBody composition in patients with CRLM is not directly linked to the presence of systemic inflammation. However, when systemic inflammation coincides with sarcopenia and/or low VAT, prognosis is adversely affected, independent of the Fong clinical prognostic score.
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