Evidence map›Paper›PMID 30377995›Full record

ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2018

Concentrations of VEGF and PlGF Decrease in Eyes After Intravitreal Conbercept Injection.

Jun Zhou, Zheng Liu, Meng Chen, Zhi-Heng Luo, Yun-Qiu Li, Guang-Ying Qi, Tao Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jun ZhouDepartment of Ophthalmology, 3201 Hospital, Xi'an Jiaotong University Health Science Center, Hanzhong, Shaanxi, China.
Zheng LiuDepartment of Ophthalmology, 3201 Hospital, Xi'an Jiaotong University Health Science Center, Hanzhong, Shaanxi, China.
Meng ChenDepartment of Ophthalmology, 3201 Hospital, Xi'an Jiaotong University Health Science Center, Hanzhong, Shaanxi, China.
Zhi-Heng LuoVitamin D Research Institute, Shaanxi University of Technology, Hanzhong, Shaanxi, China.
Yun-Qiu LiCollege of Medical Laboratory Science, Guilin Medical University, Guilin, Guangxi, China.
Guang-Ying QiCollege of Medical Laboratory Science, Guilin Medical University, Guilin, Guangxi, China.
Tao LiuDepartment of Ophthalmology, 3201 Hospital, Xi'an Jiaotong University Health Science Center, Hanzhong, Shaanxi, China. taoliustone@hz3201.com.ORCID http://orcid.org/0000-0002-7866-3598
Guilin Medical University · CNXi'an Jiaotong University · CNHanzhong Central Hospital · CNShaanxi University of Technology · CN

Funding

The key research and development program of Shaanxi province 2017ZDXM-SF-067
6 · The paper itself

Abstract

introductionConbercept is a new anti-vascular endothelial growth factor drug approved for the treatment of age-related macular degeneration by the China Food and Drug Administration (CFDA) in 2013. In this study, we for the first time evaluated the concentrations of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) after patients with proliferative diabetic retinopathy were treated with intravitreal conbercept (IVC) injection.

methodsSixteen patients with proliferative diabetic retinopathy were randomly divided into two equal groups (A and B). Nine patients with rhegmatogenous retinal detachment were used as the control group. The patients in group A received 0.5 mg IVC and their aqueous humor was collected. After 7 days, all patients underwent vitrectomy, and their aqueous and vitreous humor were collected.

resultsIn the aqueous humor, the concentrations of VEGF and PlGF were higher pre- than post-IVC injection in group A. Similarly, the concentrations of VEGF and PlGF in group A (pre-IVC) and group B were higher than those in the control group. In vitreous humor, the concentrations of VEGF and PlGF were higher in group B than those in the control group, and the concentrations of VEGF were lower in group A (post-IVC) than those in group B.

conclusionsOur study proved that the concentration of VEGF and PlGF reduced after IVC injection in aqueous humor. However, the concentration of PlGF did not reduce after IVC injection in vitreous humor.

Indexed as

Aqueous humorConberceptPlacental growth factorVascular endothelial growth factorVitreous humor

Identifiers

PMID30377995
PMCPMC6250636
OpenAlexW2899432973

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.