Evidence map›Paper›PMID 30377939›Full record

ArticleMolecular imaging and biology2019

Development of a Fluorinated Analogue of Erlotinib for PET Imaging of EGFR Mutation-Positive NSCLC.

Ofer Shamni, Hilbert Grievink, Batel Itamar, Eyal Mishani, Galith Abourbeh

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Current topics in medicinal chemistry · 2022
    Article
  4. Article
  5. Review
  6. Nuclear Theranostics in Asia: In vivo Companion Diagnostics.Nuclear medicine and molecular imaging · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ofer ShamniCyclotron/Radiochemistry/MicroPET Unit, Hadassah Hebrew University Hospital, Hadassah Medical Organization, 91120, Jerusalem, Israel.
Hilbert GrievinkCyclotron/Radiochemistry/MicroPET Unit, Hadassah Hebrew University Hospital, Hadassah Medical Organization, 91120, Jerusalem, Israel.
Batel ItamarCyclotron/Radiochemistry/MicroPET Unit, Hadassah Hebrew University Hospital, Hadassah Medical Organization, 91120, Jerusalem, Israel.
Eyal MishaniCyclotron/Radiochemistry/MicroPET Unit, Hadassah Hebrew University Hospital, Hadassah Medical Organization, 91120, Jerusalem, Israel.
Galith AbourbehCyclotron/Radiochemistry/MicroPET Unit, Hadassah Hebrew University Hospital, Hadassah Medical Organization, 91120, Jerusalem, Israel. abourbehg@hadassah.org.il.ORCID 0000-0002-6109-814X
Hadassah Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePositron emission tomography (PET) using [ PROCEDURES: 6-O-Fluoroethylerlotinib (6-O-FEE) was synthesized and its anti-proliferative activity was tested using human NSCLC cell lines. The F-18-labeled compound, 6-O-[

resultsIn vitro, 6-O-FEE had maintained the selectivity and potency of erlotinib to EGFR

conclusions6-O-[

Indexed as

HalogenationPositron-Emission TomographyAnimalsCarcinoma, Non-Small-Cell LungCell Line, TumorCell ProliferationErbB ReceptorsErlotinib HydrochlorideHumansLiverLung NeoplasmsMice, Inbred BALB CReference StandardsErbB ReceptorsErlotinib Hydrochloride6-O-[18F]FEEEGFRErlotinibFluorine-18ImagingNSCLCPETTKI

Identifiers

PMID30377939
OpenAlexW2899262411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.