Evidence map›Paper›PMID 30377931›Full record

ArticleBrain imaging and behavior2020

Brain activity pattern changes after adaptive working memory training in multiple sclerosis.

Laura Bonzano, Ludovico Pedullà, Matteo Pardini, Andrea Tacchino, Paola Zaratin, Mario Alberto Battaglia, Giampaolo Brichetto, Marco Bove

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain imaging and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  5. Review
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Laura BonzanoDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
Ludovico PedullàDepartment of Experimental Medicine, Section of Human Physiology, University of Genoa, Viale Benedetto XV 3, 16132, Genoa, Italy.
Matteo PardiniDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
Andrea TacchinoItalian Multiple Sclerosis Foundation, Scientific Research Area, Genoa, Italy.
Paola ZaratinItalian Multiple Sclerosis Foundation, Scientific Research Area, Genoa, Italy.
Mario Alberto BattagliaDepartment of Life Science, University of Siena, Siena, Italy.
Giampaolo BrichettoItalian Multiple Sclerosis Foundation, Scientific Research Area, Genoa, Italy.
Marco BoveDepartment of Experimental Medicine, Section of Human Physiology, University of Genoa, Viale Benedetto XV 3, 16132, Genoa, Italy. marco.bove@unige.it.
Associazione Italiana Sclerosi Multipla · ITUniversity of Genoa · ITOspedale Policlinico San Martino · ITUniversity of Siena · IT

Funding

Fondazione Italiana Sclerosi Multipla 2011/R/8
6 · The paper itself

Abstract

Cognitive impairment and related abnormal brain activity are common in people with multiple sclerosis (PwMS). Adaptive training based on working memory (WM) has been shown to ameliorate cognitive symptoms, although the effects at a neural level are unclear. The aim of this study was to expand the existing research on the effects of an adaptive WM rehabilitative intervention on brain functional activity in PwMS. A sample of eighteen PwMS performed an 8-week home-based cognitive rehabilitation treatment based on adaptive WM training. PwMS were assessed before and after treatment using a validated neuropsychological battery and undergoing an fMRI session while carrying out a cognitive task (i.e., Paced Visual Serial Addition Test - PVSAT). fMRI activations were compared to the activation pattern elicited by eighteen matched healthy subjects performing the same task. At baseline, we found abnormal brain activity during PVSAT in PwMS when compared to healthy subjects, with a pattern including several bilateral activation clusters. Following rehabilitation, PwMS improved cognitive performance, as evaluated by the neuropsychological battery, and showed a different activation map with clusters mainly located in the right cerebellum and in the left hemisphere. The only significant cluster in the right hemisphere was located in the inferior parietal lobule, and the BOLD signal extracted in this area significantly correlated with cognitive performance both before and after the treatment. We suggest that WM training can improve the cognitive performance and reduce the abnormal activation of PwMS by partially maintaining or even restoring brain cognitive function.

Indexed as

AdultBrainBrain MappingCerebellumCerebral CortexCognitionCognitive Behavioral TherapyCognitive DysfunctionFemaleHumansLearningMagnetic Resonance ImagingMaleMemory, Short-TermMiddle AgedMultiple SclerosisAdaptive trainingCognitive rehabilitationCognitive reservefMRIMultiple sclerosisWorking memory

Identifiers

PMID30377931
PMCPMC7007888
OpenAlexW2898619621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.