Evidence map›Paper›PMID 30377929›Full record

ReviewCognitive, affective & behavioral neuroscience2019

Substance use is associated with reduced devaluation sensitivity.

Kaileigh A Byrne, A Ross Otto, Bo Pang, Christopher J Patrick, Darrell A Worthy

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cognitive, affective & behavioral neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Habit, choice, and addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Review
  7. Article
  8. Review
  9. Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Review
  10. Article
  11. Substance use and Psychosocial Functioning of Adolescents in Benue State, Nigeria: Assessing the role of age.African journal for the psychological study of social issues : journal of the African Society for the Psychological Study of Social Issues · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Kaileigh A ByrneClemson University, Clemson, SC, USA.
A Ross OttoMcGill University, Montreal, QC, Canada.
Bo PangTexas A&M University, College Station, TX, 77843-4235, USA.
Christopher J PatrickFlorida State University, Tallahassee, FL, USA.
Darrell A WorthyTexas A&M University, College Station, TX, 77843-4235, USA. worthyda@tamu.edu.
Texas A&M University · USClemson University · USFlorida State University · USMcGill University · CA

Funding

A computational neuroscience approach to frontal compensation in decision-makingR01AG043425 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI SCHNYER, DAVID M, WORTHY, DARRELL A. · 2014 to 2019
$1.7M
NEUROCHEMICAL MECHANISMS OF ETHANOL SELF-ADMINISTRATIONR01AA011852 · NIAAA · UNIVERSITY OF TEXAS AUSTIN · PI GONZALES, RUEBEN A · 1999 to 2007
$1.6M
NIAAA NIH HHS R01 AA011852NIA NIH HHS R01 AG043425
6 · The paper itself

Abstract

Substance use has been linked to impairments in reward processing and decision-making, yet empirical research on the relationship between substance use and devaluation of reward in humans is limited. We report findings from two studies that tested whether individual differences in substance use behavior predicted reward learning strategies and devaluation sensitivity in a nonclinical sample. Participants in Experiment 1 (N = 66) and Experiment 2 (N = 91) completed subscales of the Externalizing Spectrum Inventory and then performed a two-stage reinforcement learning task that included a devaluation procedure. Spontaneous eye blink rate was used as an indirect proxy for dopamine functioning. In Experiment 1, correlational analysis revealed a negative relationship between substance use and devaluation sensitivity. In Experiment 2, regression modeling revealed that while spontaneous eyeblink rate moderated the relationship between substance use and reward learning strategies, substance use alone was related to devaluation sensitivity. These results suggest that once reward-action associations are established during reinforcement learning, substance use predicted reduced sensitivity to devaluation independently of variation in eyeblink rate. Thus, substance use is not only related to increased habit formation but also to difficulty disengaging from learned habits. Implications for the role of the dopaminergic system in habitual responding in individuals with substance use problems are discussed.

Indexed as

HabitsRewardAnimalsConditioning, OperantHumansLearningReinforcement, PsychologySubstance-Related DisordersDecision-makingDevaluationHabit formationRewardSubstance use

Identifiers

PMID30377929
PMCPMC8049538
OpenAlexW2899318582

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.