ArticleJournal of biological physics2019
Impulsive control of a nonlinear dynamical network and its application to biological networks.
Article in Journal of biological physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
The control of nonlinear dynamical systems is always a notable problem in science. According to control theory, suitable inputs for a controllable dynamical system are critical. Previous studies have shown some principles to determine control nodes and design control function. In this work, we propose a new control strategy of nonlinear systems by constructing impulsive control functions, i.e., we can realize the transition from an undesired state to a desired one by controlling appropriately chosen nodes in a discrete manner. In order to demonstrate the effectiveness of the strategy, we apply it to two biological networks: the epithelial-mesenchymal transition (EMT) network and the Notch1-Dll1-Jag1 signaling pathway. The strategy can not only be used to guide pharmacological design in a more feasible form but can also be applied into the fields of biological, medical and other multistable dynamical systems.
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