Evidence map›Paper›PMID 30377828›Full record

SynthesisMedical oncology (Northwood, London, England)2018

Effects of extracellular acidity on resistance to chemotherapy treatment: a systematic review.

Viviane Palmeira da Silva, Carulina Bueno Mesquita, Júlia Silveira Nunes, Bianca de Bem Prunes, Pantelis Varvaki Rados, Fernanda Visioli

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Medical oncology (Northwood, London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04874935 (The Possible Efficacy and Safety of Lansoprazole Co-administration With Neoadjuvant Chemotherapy in Women With Breast Cancer), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04874935 phase3completednot on this mapstarted 2021, after this paper: background citation

The Possible Efficacy and Safety of Lansoprazole Co-administration With Neoadjuvant Chemotherapy in Women With Breast Cancer

TypeinterventionalSponsorTanta UniversityRan2021 to 2022Enrolled66ConditionsBreast CancerArmsLansoprazole, Placebo
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Viviane Palmeira da SilvaOral Pathology Department, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2492/503, Porto Alegre, Rio Grande Do Sul, CEP 90035-003, Brazil.
Carulina Bueno MesquitaOral Pathology Department, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2492/503, Porto Alegre, Rio Grande Do Sul, CEP 90035-003, Brazil.
Júlia Silveira NunesOral Pathology Department, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2492/503, Porto Alegre, Rio Grande Do Sul, CEP 90035-003, Brazil.
Bianca de Bem PrunesOral Pathology Department, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2492/503, Porto Alegre, Rio Grande Do Sul, CEP 90035-003, Brazil.
Pantelis Varvaki RadosOral Pathology Department, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2492/503, Porto Alegre, Rio Grande Do Sul, CEP 90035-003, Brazil.
Fernanda VisioliOral Pathology Department, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2492/503, Porto Alegre, Rio Grande Do Sul, CEP 90035-003, Brazil. fernanda.visioli@ufrgs.br.ORCID http://orcid.org/0000-0002-4033-8431
Universidade Federal do Rio Grande do Sul · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 455496/2014-5
6 · The paper itself

Abstract

Metabolic alterations in the tumor microenvironment have a complex effect on cancer progression. Extracellular acidity is a consequence of metabolic switch in cancer and results in cell phenotypes with higher resistance to chemotherapeutics. However, mechanisms underlying the relationship between the extracellular acidity and chemoresistance are not clearly understood. This systematic review was carried out by searching the databases PubMed and EMBASE using the keywords "cancer" and "acidosis" or "acidic" and "chemoresistance" or "drug resistance." In vitro and in vivo studies that evaluated the effects of acidification of the tumor microenvironment on chemotherapeutic treatments were included. Literature reviews, letters to the editor, and articles that were not published in English were excluded. The search resulted in a total of 352 articles. After discarding 75 duplicate references, 277 articles were analyzed by sequentially reading through their titles, abstracts, and finally full-text. A total of 14 articles was selected. Acidification of the tumor microenvironment can trigger resistance through different mechanisms, such as increase in drug efflux transporters, inhibition of proton pumps, induction of the unfolded protein response (UPR), and cellular autophagy.

Indexed as

Drug Resistance, NeoplasmAnimalsAntineoplastic AgentsAutophagyHumansHydrogen-Ion ConcentrationMembrane Transport ProteinsNeoplasmsTumor MicroenvironmentUnfolded Protein ResponseAntineoplastic AgentsMembrane Transport ProteinsAutophagyChemoresistanceDrug efflux transportersProton pumpTumor acidosisUnfolded protein response

Identifiers

PMID30377828
OpenAlexW2898787300

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.