ReviewEuropean journal of applied physiology2019
The interactions of physical activity, exercise and genetics and their associations with bone mineral density: implications for injury risk in elite athletes.
Review in European journal of applied physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genetics and athletic performance: a systematic SWOT analysis of non-systematic reviews.Frontiers in genetics · 2023Pooled it
- Systematic Review and Meta-Analysis of Candidate Gene Association Studies With Fracture Risk in Physically Active Participants.Frontiers in genetics · 2020Pooled it
- Retrospective cross-sectional associations of whole blood cell count and hemoglobin level with lumbar bone mineral density in older adults.The Journal of international medical research · 2026Article
- A Large-Scale Multi-omics Polygenic Risk Score Analysis Identified Candidate Biomarkers Associated with Heel Bone Mineral Density.Calcified tissue international · 2026Article
- Determinants of forearm bone mineral density in male athletes with different osteogenic index of training.Scientific reports · 2025Article
- Association of hemoglobin-to-red blood cell distribution width ratio and bone mineral density in older adults.BMC musculoskeletal disorders · 2024Article
- From Genomics to Metabolomics: Molecular Insights into Osteoporosis for Enhanced Diagnostic and Therapeutic Approaches.Biomedicines · 2024Review
- Effects of acute- and long-term aerobic exercises at different intensities on bone in mice.Journal of bone and mineral metabolism · 2024Article
- Correlation of Acceleration Curves in Gravitational Direction for Different Body Segments during High-Impact Jumping Exercises.Sensors (Basel, Switzerland) · 2023Article
- Review
- Sport Activity Load and Skeletomuscular Robustness in Elite Youth Athletes.International journal of environmental research and public health · 2022Article
- Bone mineral density in high-level endurance runners: Part B-genotype-dependent characteristics.European journal of applied physiology · 2022Article
- Reference values for bone density and bone mineral content from 5 to 80 years old in a province of Chile.PeerJ · 2022Article
- Bone mineral density in high-level endurance runners: part A-site-specific characteristics.European journal of applied physiology · 2021Article
- Molecular Portrait of an Athlete.Diagnostics (Basel, Switzerland) · 2021Review
- Long-Term Patterns of Bone Mineral Density in an Elite Soccer Player.Frontiers in physiology · 2021Article
- Genetic Basis of Aerobically Supported Voluntary Exercise: Results from a Selection Experiment with House Mice.Genetics · 2020Article
- Bone Mineral Reference Values for Athletes 11 to 20 Years of Age.International journal of environmental research and public health · 2020Article
- Knee Scooter-Related Injuries: A Survey of Foot and Ankle Orthopedic Surgeons.Foot & ankle orthopaedics · 2020Article
- Calcium-Sensing Receptor Gene Polymorphisms (CASRV1 and CASRV2) and the Physical Activity Level of Men in Lower Silesia, Poland.Frontiers in genetics · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low bone mineral density (BMD) is established as a primary predictor of osteoporotic risk and can also have substantial implications for athlete health and injury risk in the elite sporting environment. BMD is a highly multi-factorial phenotype influenced by diet, hormonal characteristics and physical activity. The interrelationships between such factors, and a strong genetic component, suggested to be around 50-85% at various anatomical sites, determine skeletal health throughout life. Genome-wide association studies and case-control designs have revealed many loci associated with variation in BMD. However, a number of the candidate genes identified at these loci have no known associated biological function or have yet to be replicated in subsequent investigations. Furthermore, few investigations have considered gene-environment interactions-in particular, whether specific genes may be sensitive to mechanical loading from physical activity and the outcome of such an interaction for BMD and potential injury risk. Therefore, this review considers the importance of physical activity on BMD, genetic associations with BMD and how subsequent investigation requires consideration of the interaction between these determinants. Future research using well-defined independent cohorts such as elite athletes, who experience much greater mechanical stress than most, to study such phenotypes, can provide a greater understanding of these factors as well as the biological underpinnings of such a physiologically "extreme" population. Subsequently, modification of training, exercise or rehabilitation programmes based on genetic characteristics could have substantial implications in both the sporting and public health domains once the fundamental research has been conducted successfully.
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