ArticleMolecular genetics and genomics : MGG2019
Identification of critical sex-biased genes in Andrias davidianus by de novo transcriptome.
Article in Molecular genetics and genomics : MGG, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Cultured Chinese Giant Salamander Skin and Skin Secretions as a Source of Bioactive Peptides for Food and Medicine.Food science of animal resources · 2025Review
- Identification and Expression Analysis ofLife (Basel, Switzerland) · 2023Article
- Comprehensive Transcriptome Analysis of Gonadal and Somatic Tissues for Identification of Sex-Related Genes in the Largemouth Bass Micropterus salmoides.Marine biotechnology (New York, N.Y.) · 2022Article
- Molecular Identification ofFrontiers in immunology · 2022Article
- Potential antagonistic relationship ofFrontiers in molecular biosciences · 2022Article
- A high-density genetic map construction and sex-related loci identification in Chinese Giant salamander.BMC genomics · 2021Article
- Environmental Temperatures Affect the Gastrointestinal Microbes of the Chinese Giant Salamander.Frontiers in microbiology · 2021Article
- Genome-Wide DNA Methylation and RNA Analysis Reveal Potential Mechanism of Resistance toJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- Genome-wide RAD sequencing to identify a sex-specific marker in Chinese giant salamander Andrias davidianus.BMC genomics · 2019Article
- The First Transcriptome Assembly of Yenyuan Stream Salamander (International journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Chinese giant salamander Andrias davidianus is a protected amphibian with high nutritional and economic value. Understanding its sex determination mechanism is important for improving culture techniques and sex control in breeding. However, little information on the characterization of critical genes involved in sex is available. Herein, sequencing of ovary and test produced 40,783,222 and 46,128,902 raw reads, respectively, which were jointly assembled into 80,497 unigenes. Of these, 36,609 unigenes were annotated, of which 8907 were female-biased and 10,385 were male-biased. Several sex-related pathways were observed, including the Wnt signaling pathway. After elevated temperature and estrogen exposure, neomale and neofemale specimens were identified by a female-specific marker for the first time. RT-qPCR analysis showed the expression profile of ten selected sex-biased genes to be exhibited consistently in male and neomale and in female and neofemale, with the exception of the Amh and TfIIIa genes. Results suggested that these genes may play important roles in A. davidianus sex determination and gonad development. This provides a basis for further investigation of the molecular mechanisms of sex determination in amphibians.
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