ArticlePediatric cardiology2019
Advanced Heart Block in Children with Lyme Disease.
Article in Pediatric cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Acute Decompensation Requiring Cardiopulmonary Resuscitation in a 15-Year-Old With Undiagnosed Lyme Carditis.Cureus · 2026Article
- A tale of 2 teammates: A pediatric case report exploring long-term outcomes of Lyme carditis.HeartRhythm case reports · 2025Article
- Antiarrhythmic Drug Dosing in Children-Review of the Literature.Children (Basel, Switzerland) · 2023Review
- Lyme Disease in Humans.Current issues in molecular biology · 2021Article
- Article
- Chest palpitations in a teenager as an unusual presentation of Lyme disease: case report.BMC infectious diseases · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinical course of children with advanced heart block secondary to Lyme disease has not been well characterized.
objectiveTo review the presentation, management, and time to resolution of heart block due to Lyme disease in previously healthy children.
methodsAn IRB approved single-center retrospective study was conducted of all patients < 21 years old with confirmed Lyme disease and advanced second or third degree heart block between 2007 and 2017.
resultsTwelve patients (100% male) with a mean age of 15.9 years (range 13.2-18.1) were identified. Six patients (50%) had mild to moderate atrioventricular valve regurgitation and all had normal biventricular function. Five patients had advanced second degree heart block and 7 had complete heart block with an escape rate of 20-57 bpm. Isoproterenol was used in 4 patients for 3-4 days and one patient required transvenous pacing for 2 days. Patients were treated with 21 days (n = 6, 50%) or 28 days (n = 6, 50%) of antibiotics. Three patients received steroids for 3-4 days. Advanced heart block resolved in all patients within 2-5 days, and all had a normal PR interval within 3 days to 16 months from hospital discharge.
conclusionSymptomatic children who present with new high-grade heart block from an endemic area should be tested for Lyme disease. Antibiotic therapy provides quick and complete resolution of advanced heart block within 5 days, while steroids did not appear to shorten the time course in this case series. Importantly, no patients required a permanent pacemaker.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.