ReviewPsychopharmacology2019
Rodent models of impaired fear extinction.
Review in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genome-wide Scan of Dental Fear and Anxiety Nominates Novel Genes.Journal of dental research · 2022Pooled it
- Pooled it
- Phospholipase A2 downregulates inhibitory transmission in the amygdala and impairs fear extinction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Ginkgo biloba extract mitigates behavioral deficits, oxidative stress, and hippocampal remodeling in a rat model of PTSD.Behavioral and brain functions : BBF · 2026Article
- Pre-trauma cognitive traits predict fear generalization and associated prefrontal functioning in a longitudinal rodent model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Acute and chronic cannabis vapor exposure produces immediate and delayed impacts on phases of fear learning in a sex specific manner.Psychopharmacology · 2026Article
- Multiple-Context Training Enhances Generalization of Cued Fear Extinction and Requires the Dorsal Hippocampus.bioRxiv : the preprint server for biology · 2026Article
- Sexually dimorphic effects of single prolonged stress on conditioned suppression behavior in Long Evans rats with no detection of altered mRNA expression of VGLUT1, GAD1, and Arc in the ventral hippocampus.Frontiers in behavioral neuroscience · 2026Article
- When Safety Fails to Update: Altered Dopamine Prediction Signals in Extinction-Deficient Mice.eNeuro · 2026Article
- Article
- Mild Traumatic Brain Injury Impairs Fear Extinction and Network Excitability in the Infralimbic Cortex.Journal of neurotrauma · 2025Article
- Exposure to unpredictable childhood environments is associated with amygdala activation during early extinction in adulthood.Developmental cognitive neuroscience · 2025Article
- Brain mechanisms underlying the inhibitory control of thought.Nature reviews. Neuroscience · 2025Review
- Dopamine release and dopamine-related gene expression in the amygdala are modulated by the gastrin-releasing peptide in opposite directions during stress-enhanced fear learning and extinction.Molecular psychiatry · 2025Article
- Amygdala intercalated cells form an evolutionarily conserved system orchestrating brain networks.Nature neuroscience · 2025Review
- Ventral hippocampal interneurons govern extinction and relapse of contextual associations.Cell reports · 2024Article
- Intra-BLA alteration of interneurons' modulation of activity in rats, reveals a dissociation between effects on anxiety symptoms and extinction learning.Neurobiology of stress · 2024Article
- Glucocorticoid effects on the brain: from adaptive developmental plasticity to allostatic overload.The Journal of experimental biology · 2024Review
- Fear extinction rescuing effects of dopamine and L-DOPA in the ventromedial prefrontal cortex.Translational psychiatry · 2024Article
- Alleviating anxiety and taming trauma: Novel pharmacotherapeutics for anxiety disorders and posttraumatic stress disorder.Neuropharmacology · 2023Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The measurement of Pavlovian forms of fear extinction offers a relatively simple behavioral preparation that is nonetheless tractable, from a translational perspective, as an approach to study mechanisms of exposure therapy and biological underpinnings of anxiety and trauma-related disorders such as post-traumatic stress disorder (PTSD). Deficient fear extinction is considered a robust clinical endophenotype for these disorders and, as such, has particular significance in the current "age of RDoC (research domain criteria)." Various rodent models of impaired extinction have thus been generated with the objective of approximating this clinical, relapse prone aberrant extinction learning. These models have helped to reveal neurobiological correlates of extinction circuitry failure, gene variants, and other mechanisms underlying deficient fear extinction. In addition, they are increasingly serving as tools to investigate ways to therapeutically overcome poor extinction to support long-term retention of extinction memory and thus protection against various forms of fear relapse; modeled in the laboratory by measuring spontaneous recovery, reinstatement and renewal of fear. In the current article, we review models of impaired extinction built around (1) experimentally induced brain region and neural circuit disruptions (2) spontaneously-arising and laboratory-induced genetic modifications, or (3) exposure to environmental insults, including stress, drugs of abuse, and unhealthy diet. Collectively, these models have been instrumental in advancing in our understanding of extinction failure and underlying susceptibilities at the neural, genetic, molecular, and neurochemical levels; generating renewed interest in developing novel, targeted and effective therapeutic treatments for anxiety and trauma-related disorders.
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