Trial reportDiabetologia2019
Effect of L-arginine on energy metabolism, skeletal muscle and brown adipose tissue in South Asian and Europid prediabetic men: a randomised double-blinded crossover study.
Trial report in Diabetologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02291458 (The Effect of L-arginine on Brown Adipose Tissue Metabolism in South Asian and White Caucasian Subjects), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of L-arginine on Brown Adipose Tissue Metabolism in South Asian and White Caucasian Subjects
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Effects of Nutrition/Diet on Brown Adipose Tissue in Humans: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Higher Plasma Sclerostin and Lower Wnt Signaling Gene Expression in White Adipose Tissue of Prediabetic South Asian Men Compared with White Caucasian Men.Diabetes & metabolism journal · 2020Trial
- The impact of sports supplements on metabolism, glycemic control, and lipid profile in adolescents and young adults: a narrative review.Pediatric endocrinology, diabetes, and metabolism · 2026Review
- Review
- Evaluation of dietary arginine supplementation to increase placental nutrient transporters in aged mares.Translational animal science · 2023Article
- L-Arginine increases AMPK phosphorylation and the oxidation of energy substrates in hepatocytes, skeletal muscle cells, and adipocytes.Amino acids · 2022Article
- Dietary L-arginine supplementation increases the hepatic expression of AMP-activated protein kinase in rats.Amino acids · 2022Article
- Ethnic disparities attributed to the manifestation in and response to type 2 diabetes: insights from metabolomics.Metabolomics : Official journal of the Metabolomic Society · 2022Review
- Paracrine Role of the Endothelium in Metabolic Homeostasis in Health and Nutrient Excess.Frontiers in cardiovascular medicine · 2022Review
- Impacts of Selected Dietary Nutrient Intakes on Skeletal Muscle Insulin Sensitivity and Applications to Early Prevention of Type 2 Diabetes.Advances in nutrition (Bethesda, Md.) · 2021Review
- Short-Term Cooling Increases Plasma ANGPTL3 and ANGPTL8 in Young Healthy Lean Men but Not in Middle-Aged Men with Overweight and Prediabetes.Journal of clinical medicine · 2019Article
- Effects of dietary arginine supplementation in pregnant mares on maternal metabolism, placental structure and function and foal growth.Scientific reports · 2019Article
- A Noninvasive Accurate Measurement of Blood Glucose Levels with Raman Spectroscopy of Blood in Microvessels.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisIndividuals of South Asian origin are at increased risk of developing type 2 diabetes mellitus and associated comorbidities compared with Europids. Disturbances in energy metabolism may contribute to this increased risk. Skeletal muscle and possibly also brown adipose tissue (BAT) are involved in human energy metabolism and nitric oxide (NO) is suggested to play a pivotal role in regulating mitochondrial biogenesis in both tissues. We aimed to investigate the effects of 6 weeks of supplementation with L-arginine, a precursor of NO, on energy metabolism by BAT and skeletal muscle, as well as glucose metabolism in South Asian men compared with men of European descent.
methodsWe included ten Dutch South Asian men (age 46.5 ± 2.8 years, BMI 30.1 ± 1.1 kg/m
resultsL-Arginine did not affect BMR, [ CONCLUSIONS/
interpretationL-Arginine supplementation does not affect BMR, [
fundingThis study was funded by the EU FP7 project DIABAT, the Netherlands Organization for Scientific Research, the Dutch Diabetes Research Foundation and the Dutch Heart Foundation.
trial registrationClinicalTrials.gov NCT02291458.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.