Evidence map›Paper›PMID 30377672›Full record

ArticleBiochemistry and biophysics reports2018

Bone marrow-derived mesenchymal stem cells inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia after arterial injury in rats.

Yoshitaka Iso, Sayaka Usui, Masashi Toyoda, Jeffrey L Spees, Akihiro Umezawa, Hiroshi Suzuki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Impact of the transforming growth factor-β pathway on vascular restenosis and its mechanism.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Yoshitaka IsoDivision of Cardiology, Department of Internal Medicine, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Yokohama City, Kanagawa 227-8518, Japan.
Sayaka UsuiDivision of Cardiology, Department of Internal Medicine, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Yokohama City, Kanagawa 227-8518, Japan.
Masashi ToyodaVascular Medicine, Tokyo Metropolitan Institute of Gerontology, 2-35 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan.
Jeffrey L SpeesDepartment of Medicine, Stem Cell Core, University of Vermont, 208 South Park Drive, Ste 2, Colchester, VT 05446, USA.
Akihiro UmezawaCenter for Regenerative Medicine, National Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.
Hiroshi SuzukiDivision of Cardiology, Department of Internal Medicine, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Yokohama City, Kanagawa 227-8518, Japan.
Showa University Fujigaoka Hospital · JPNational Center For Child Health and Development · JPTokyo Metropolitan Institute of Gerontology · JPUniversity of Vermont · US

Funding

Vascular protection by HGF/IgG protein complexes that activate RYKR01HL132264 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SPEES, JEFFREY L · 2016 to 2019
$1.5M
Control of reactive astrocytes by Notch1 and Amyloid Precursor ProteinR01NS073815 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SPEES, JEFFREY L · 2012 to 2015
$1.3M
NHLBI NIH HHS R01 HL132264NINDS NIH HHS R01 NS073815
6 · The paper itself

Abstract

We investigated whether mesenchymal stem cell (MSC)-based treatment could inhibit neointimal hyperplasia in a rat model of carotid arterial injury and explored potential mechanisms underlying the positive effects of MSC therapy on vascular remodeling/repair. Sprague-Dawley rats underwent balloon injury to their right carotid arteries. After 2 days, we administered cultured MSCs from bone marrow of GFP-transgenic rats (0.8 × 10

Indexed as

CdM, conditioned medium CCM: complete culture mediumGAPDH, glyceraldehyde-3-phosphate dehydrogenaseICAM-1, intercellular adhesion molecule-1IEL, internal elastic lamina EEL: external elastic laminaIL-6, interleukin-6 MCP-1: monocyte chemoattractant protein-1Mesenchymal stem cellsMSC, mesenchymal stem cell GFP: green fluorescence proteinNeointimal hyperplasiaStem cell-secreted factorsVascular smooth muscle cellsVSMC, vascular smooth muscle cell PDGF: platelet-derived growth factor

Identifiers

PMID30377672
PMCPMC6202691
OpenAlexW2898593551

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.