Evidence map›Paper›PMID 30377660›Full record

ArticleBioengineering & translational medicine2018

Engineered E. coli Nissle 1917 for the reduction of vancomycin-resistant

Kathryn G Geldart, Sushma Kommineni, Madeline Forbes, Michael Hayward, Gary M Dunny, Nita H Salzman, Yiannis N Kaznessis

Open access · goldAbstract read
In one paragraph

Article in Bioengineering & translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 84 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Prevalence and activity of class II microcins inApplied and environmental microbiology · 2026
    Article
  6. Review
  7. An Engineered Variant ofACS synthetic biology · 2026
    Article
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  11. Review
  12. Review
  13. Review
  14. Article
  15. Enhancing Resistance toNutrients · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Synthetic Biology-Driven Microbial Therapeutics for Disease Treatment.Journal of microbiology and biotechnology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Kathryn G GeldartGeneral Probiotics Inc. St. Paul MN 55114.
Sushma KommineniMerck Cambridge MA 02141.
Madeline ForbesTakeda Pharmaceuticals Minneapolis MN 55455.
Michael HaywardDepartment of Pediatrics Medical College of Wisconsin Milwaukee WI 53226.
Gary M DunnyDepartment of Microbiology and Immunology University of Minnesota Minneapolis MN 55455.
Nita H SalzmanDepartment of Pediatrics Medical College of Wisconsin Milwaukee WI 53226.
Yiannis N KaznessisGeneral Probiotics Inc. St. Paul MN 55114.ORCID 0000-0002-5088-1104
Medical College of Wisconsin · USUniversity of Minnesota · USCardiovascular Systems (United States) · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USTakeda (United States) · US

Funding

Intestinal Enterococcal Dynamics: Modeling Host-Commensal and Host-Pathogen InteractionsR35GM122503 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI SALZMAN, NITA H · 2017 to 2021
$2.7M
Lactic Acid Bacteria that Detect & Inhibit Enterococci in the Mammalian GI TractR01GM111358 · NIGMS · UNIVERSITY OF MINNESOTA · PI DUNNY, GARY M, KAZNESSIS, YIANNIS · 2014 to 2017
$1.4M
Bacterial-host dynamics at the intestinal mucosal interfaceR01GM099526 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI SALZMAN, NITA H · 2012 to 2015
$1.4M
NIGMS NIH HHS R01 GM099526NIGMS NIH HHS R01 GM111358NIGMS NIH HHS R35 GM122503
6 · The paper itself

Abstract

Vancomycin-resistant

Indexed as

antimicrobial peptidesantimicrobialsbacteriocinsE. coli Nissle 1917microbiome engineeringsynthetic biologyvancomycin‐resistant enterococcus

Identifiers

PMID30377660
PMCPMC6195901
OpenAlexW2885058058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.