ReviewTemperature (Austin, Tex.)2018
Cardiovascular diseases, cold exposure and exercise.
Review in Temperature (Austin, Tex.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 3 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Impact of cold waves on diabetes-related morbidity and mortality: a meta-analysis.Frontiers in public health · 2025Pooled it
- Brazilian Guideline for Exercise Testing in Children and Adolescents - 2024.Arquivos brasileiros de cardiologia · 2024Guideline
- Impacts of exposure to humidex on cardiovascular mortality: a multi-city study in Southwest China.BMC public health · 2023Pooled it
- Central aortic hemodynamics following acute lower and upper-body exercise in a cold environment among patients with coronary artery disease.Scientific reports · 2021Trial
- Good safety practice in a randomized controlled trial (CadColdEx) involving increased cardiac workload in patients with coronary artery disease.BMC cardiovascular disorders · 2019Trial
- Lack of guidelines for cold exposure among vulnerable outdoor workers.International journal of circumpolar health · 2026Review
- Ambient air temperature and out-of-hospital cardiac arrest: A national case-crossover study.Journal of internal medicine · 2026Article
- Translating Population-Based Epidemiology into Clinical Recognition of Coronary Artery Spasm: Prevalence, Incidence, and Geographic-Seasonal Variation in Taiwan.Medical sciences (Basel, Switzerland) · 2026Article
- Assessment of readiness for return to skiing after coronary artery bypass grafting and left ventricular reconstruction using cardiopulmonary exercise testing and field-based expiratory gas analysis: a case report.European heart journal. Case reports · 2026Article
- Association between ambient temperature and acute type A aortic dissection in a Korean population: a 12-year dual-scale Poisson regression analysis.Journal of thoracic disease · 2026Article
- Ambient cold exposure and myocardial infarction risk in Tianjin, China: a distributed lag non-linear analysis.BMC public health · 2026Article
- Interaction of Extreme Temperature Events and Nitrogen Dioxide on Out-of-Hospital Cardiac Arrest in a Subtropical Megacity: A Time-Series Analysis.Journal of the American Heart Association · 2026Article
- Nighttime Cold Stress and Cardiovascular Emergency Hospitalizations: A Time-Series Analysis by Sex and Age in a Subtropical City.Journal of the American Heart Association · 2026Article
- Associations between extreme temperatures and hospitalizations among Chinese cancer patients with atrial fibrillation: a case-crossover study.Cardio-oncology (London, England) · 2026Article
- Differential Association Between Surrounding Greenness and Mortality in Individuals With Coronary Heart Disease.JACC. Advances · 2026Article
- Mortality risk due to non-optimum temperatures by cause of death, age, and sex: a multi-country time-series study.EClinicalMedicine · 2026Article
- MiR-499-5P/PACS2/TRPV1 Axis Maintains Mitochondrial Homeostasis and Left Ventricular Function after Extreme Cold Stress.Journal of cardiovascular translational research · 2026Article
- Review
- Cold-induced vasodilation: A meta-analysis.Temperature (Austin, Tex.) · 2026Review
- Environmental cold exposure and cardiovascular mortality: biological mechanisms, regional heterogeneity, and public health implications.Frontiers in public health · 2026Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both acute and prolonged cold exposure affect cardiovascular responses, which may be modified by an underlying cardiovascular disease. In addition, exercise in a cold environment increases cardiovascular strain further, but its effects among persons with cardiovascular diseases are not well known. Controlled studies employing whole-body or local cold exposure demonstrate comparable or augmented increase in cardiac workload, but aggravated cutaneous vasoconstriction in persons with mild hypertension. A strong sympathetic stimulation of a cold pressor test, increases cardiac workload in persons with coronary artery disease (CAD), but does not markedly differ from those with less severe disease or healthy. However, cold exposure reduces myocardial oxygen supply in CAD, which may lead to ischemia. Exercise in cold often augments cardiac workload in persons with CAD more than when performed in thermoneutral conditions. At the same time, reduced myocardial perfusion may lead to earlier ischemia, angina and impaired performance. Also having a heart failure deteriorates submaximal and maximal performance in the cold. Antianginal medication is beneficial in the cold in lowering blood pressure, but does not affect the magnitude of cold-related cardiovascular responses in hypertension. Similarly, the use of blood pressure lowering medication improves exercise performance in cold both among persons with CAD and heart failure. Both the acute and seasonal effects of cold and added with exercise may contribute to the higher morbidity and mortality of those with cardiovascular diseases. Yet, more controlled studies for understanding the pathophysiological mechanisms behind the adverse cold-related health effects are warranted.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.