Evidence map›Paper›PMID 30377564›Full record

ArticleOncoimmunology

Enhanced gut barrier integrity sensitizes colon cancer to immune therapy.

Neal Bhutiani, Qingsheng Li, Charles D Anderson, Heather C Gallagher, Magdia De Jesus, Rajbir Singh, Venkatkrishna R Jala, Mostafa Fraig, Tao Gu, Nejat K Egilmez

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Emerging Complexity in CD4Frontiers in immunology · 2021
    Review
  8. Article
  9. Disease models & mechanisms · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Neal BhutianiDepartment of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, USA.
Qingsheng LiDepartment of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, USA.
Charles D AndersonDepartment of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, USA.
Heather C GallagherDepartment of Biomedical Sciences, University at Albany School of Public Health, One University Place Rensselaer Albany, USA.
Magdia De JesusDepartment of Biomedical Sciences, University at Albany School of Public Health, One University Place Rensselaer Albany, USA.
Rajbir SinghDepartment of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, USA.
Venkatkrishna R JalaDepartment of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, USA.
Mostafa FraigDepartment of Pathology, School of Medicine, University of Louisville, Louisville, USA.
Tao GuDepartment of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, USA.
Nejat K EgilmezDepartment of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, USA.
University of Louisville · USNew York State Department of Health · USUniversity at Albany, State University of New York · US

Funding

Integrating innate and adaptive immunity in cancer therapyR01CA100656 · NCI · UNIVERSITY OF LOUISVILLE · PI EGILMEZ, NEJAT K · 2004 to 2014
$2.9M
NCI NIH HHS R01 CA100656
6 · The paper itself

Abstract

Oral IL-10 suppressed tumor growth in the APC

Indexed as

colon cancergut epithelial barrierIL-10IL-12IL-17

Identifiers

PMID30377564
PMCPMC6204984
OpenAlexW2888540431

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.