ReviewReproductive medicine and biology2018
Molecular mechanisms of embryonic implantation in mammals: Lessons from the gene manipulation of mice.
Review in Reproductive medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- The dual roles of uterine monocytes in regulation of tissue homeostasis throughout reproductive cycles in health and disease.Nature immunology · 2026Article
- Generation and Characterization of a Rdh1-iCre Line to Study Uterine Glandular Biology.Genesis (New York, N.Y. : 2000) · 2026Article
- Ferroptosis in veterinary medicine: mechanisms, therapies, and unmet challenges.The veterinary quarterly · 2025Review
- Dynamic changes in sumoylation related proteins SUMO1, SENP1, and UBC9 during the peri implantation period in mice.Scientific reports · 2025Article
- LIFR-Mediated ERBB2 Signaling Is Essential for Successful Embryo Implantation in Mice.Biomolecules · 2025Article
- Revolutionizing Implantation Studies: Uterine-Specific Models and Advanced Technologies.Biomolecules · 2025Review
- Endometrial zinc transporterPNAS nexus · 2025Article
- Comparative Analysis of Controlled Ovarian Hyperstimulation and Modified Natural Cycle Protocols on Gene Expression and Quality of Oocytes, Zygotes, and Embryos in Assisted Reproductive Technology (ART).International journal of molecular sciences · 2024Article
- 3DMOUSEneST: a volumetric label-free imaging method evaluating embryo-uterine interaction and decidualization efficacy.Development (Cambridge, England) · 2024Article
- The histone methyltransferase KMT2D is essential for embryo implantation via regulating precise differentiation of endometrial cells.Cell death discovery · 2024Article
- Immune Regulation of Seminal Plasma on the Endometrial Microenvironment: Physiological and Pathological Conditions.International journal of molecular sciences · 2023Review
- The investigation of hippo signaling pathway in mouse uterus during peri-implantation period.Archives of gynecology and obstetrics · 2023Article
- Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice.Scientific reports · 2023Article
- An In Vivo Screening Model for Investigation of Pathophysiology of Human Implantation Failure.Biomolecules · 2022Review
- Mouse Cre drivers: tools for studying disorders of the human female neuroendocrine-reproductive axis†.Biology of reproduction · 2022Review
- Defining recurrent implantation failure: a profusion of confusion or simply an illusion?Fertility and sterility · 2021Review
- Probing morphological, genetic and metabolomic changes of in vitro embryo development in a microfluidic device.Biotechnology progress · 2021Article
- Role of adipokines in embryo implantation.Endocrine connections · 2021Review
- Male-derived copulatory plugs enhance implantation success in female Mus musculus.Biology of reproduction · 2021Article
- Integrating LCM-Based Spatio-Temporal Transcriptomics Uncovers Conceptus and Endometrial Luminal Epithelium Communication that Coordinates the Conceptus Attachment in Pigs.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman infertility has become a serious and social issue all over the world, especially in developed countries. Numerous types of assisted reproductive technology have been developed and are widely used to treat infertility. However, pregnancy outcomes require further improvement. It is essential to understand the cross-talk between the uterus (mother) and the embryo (fetus) in pregnancy, which is a very complicated event.
methodsThe mammalian uterus requires many physiological and morphological changes for pregnancy-associated events, including implantation, decidualization, placentation, and parturition, to occur. Here is discussed recent advances in the knowledge of the molecular mechanisms underlying these reproductive events - in particular, embryonic implantation and decidualization - based on original and review articles. MAIN FINDINGS
resultsIn mice, embryonic implantation and decidualization are regulated by two steroid hormones: estrogen and progesterone. Along with these hormones, cytokines, cell-cycle regulators, growth factors, and transcription factors have essential roles in implantation and decidualization in mice.
conclusionRecent studies using the gene manipulation of mice have given considerable insight into the molecular mechanisms underlying embryonic implantation and decidualization. However, as most of the findings are based on mice, comparative research using different mammalian species will be useful for a better understanding of the species-dependent differences that are associated with reproductive events, including embryonic implantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.