Evidence map›Paper›PMID 30377277›Full record

ArticlemBio2018

A Secreted Bacterial Peptidylarginine Deiminase Can Neutralize Human Innate Immune Defenses.

Tim Stobernack, Marines du Teil Espina, Lianne M Mulder, Laura M Palma Medina, Dillon R Piebenga, Giorgio Gabarrini, Xin Zhao, Koen M J Janssen, Jarnick Hulzebos, Elisabeth Brouwer and 7 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pathogenesis ofFrontiers in cellular and infection microbiology · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Oral Microbiome Dysbiosis and Citrullination in Rheumatoid Arthritis.Advances in experimental medicine and biology · 2025
    Review
  8. Review
  9. Review
  10. Cryoablation-induced neutrophil CaJournal of experimental & clinical cancer research : CR · 2024
    Article
  11. Review
  12. Review
  13. AmSystems · 2024
    Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. International journal of molecular sciences · 2023
    Article
  20. Postbiotic Metabolite ofPharmaceutics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Tim Stobernack *Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Marines du Teil Espina *Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Lianne M MulderDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Laura M Palma MedinaDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Dillon R PiebengaDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Giorgio GabarriniDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Xin ZhaoDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Koen M J JanssenDepartment of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jarnick HulzebosDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Elisabeth BrouwerDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Thomas SuraInstitute for Microbiology, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
Dörte BecherInstitute for Microbiology, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
Arie Jan van WinkelhoffDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Friedrich GötzMicrobial Genetics, Interfaculty Institute of Microbiology and Infection Medicine and Infection Medicine (IMIT), University of Tübingen, Tübingen, Germany.
Andreas OttoInstitute for Microbiology, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
Johanna WestraDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jan Maarten van DijlDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands j.m.van.dijl01@umcg.nl.
University Medical Center Groningen · NLUniversity of Groningen · NLUniversität Greifswald · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The keystone oral pathogen

Indexed as

Immune EvasionAdultAntimicrobial Cationic PeptidesExtracellular TrapsFemaleGingivaHumansImmunity, InnateMalePeriodontitisPhagocytosisPorphyromonas gingivalisProtein-Arginine DeiminasesVirulence FactorsAntimicrobial Cationic PeptidesProtein-Arginine DeiminasesVirulence Factorscitrullinationimmune evasionneutrophilsPorphyromonas gingivalisprotein modification

Identifiers

PMID30377277
PMCPMC6212822
OpenAlexW2899299976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.