Evidence map›Paper›PMID 30377275›Full record

ArticlemBio2018

Genome-Wide Characterization of the Fur Regulatory Network Reveals a Link between Catechol Degradation and Bacillibactin Metabolism in Bacillus subtilis.

Hualiang Pi, John D Helmann

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Iron-dependent mechanisms inJAC-antimicrobial resistance · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hualiang PiDepartment of Microbiology, Cornell University, Ithaca, New York, USA.
John D HelmannDepartment of Microbiology, Cornell University, Ithaca, New York, USA jdh9@cornell.edu.ORCID 0000-0002-3832-3249
Cornell University · US

Funding

Bacillus subtilis Stress ResponsesR35GM122461 · NIGMS · CORNELL UNIVERSITY · PI John D Helmann · 2017 to 2026
$7.6M
NIGMS NIH HHS R35 GM122461
6 · The paper itself

Abstract

The ferric uptake regulator (Fur) is the global iron biosensor in many bacteria. Fur functions as an iron-dependent transcriptional repressor for most of its regulated genes. There are a few examples where holo-Fur activates transcription, either directly or indirectly. Recent studies suggest that apo-Fur might also act as a positive regulator and that, besides iron metabolism, the Fur regulon might encompass other biological processes such as DNA synthesis, energy metabolism, and biofilm formation. Here, we obtained a genomic view of the Fur regulatory network in

Indexed as

Gene Expression Regulation, BacterialBacillus subtilisBinding SitesBiotransformationCatecholsChromatin ImmunoprecipitationDNA, BacterialGene Expression ProfilingGene Regulatory NetworksOligopeptidesPromoter Regions, GeneticProtein BindingRepressor ProteinsSequence Analysis, DNAbacillibactincatecholCatecholsDNA, BacterialOligopeptidesRepressor Proteinsbacillibactin degradationbacillibactin metabolismcatechol degradationChIP-seqFur regulon

Identifiers

PMID30377275
PMCPMC6212828
OpenAlexW2950895305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.