Evidence map›Paper›PMID 30377224›Full record

ArticleScience signaling2018

Modulation of Cl

Laura Vachel, Nikolay Shcheynikov, Osamu Yamazaki, Moran Fremder, Ehud Ohana, Aran Son, Dong Min Shin, Ai Yamazaki-Nakazawa, Chin-Rang Yang, Mark A Knepper and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science signaling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Inactivation mechanisms of NaCommunications biology · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. CaCold Spring Harbor perspectives in biology · 2020
    Review
  10. ClAmerican journal of physiology. Cell physiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Laura VachelEpithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Nikolay ShcheynikovEpithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Osamu YamazakiEpithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Moran FremderDepartment of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel.
Ehud OhanaDepartment of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel.
Aran SonEpithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-4487-7026
Dong Min ShinDepartment of Oral Biology, BK 21 PLUS Project, Yonsei University College of Dentistry, Seoul 120-752, Korea.ORCID 0000-0001-6042-0435
Ai Yamazaki-NakazawaEpithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Chin-Rang YangEpithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Mark A KnepperEpithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-2276-8091
Shmuel MuallemEpithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. shmuel.muallem@nih.gov.
National Institutes of Health · USBen-Gurion University of the Negev · ILNational Heart Lung and Blood Institute · USYonsei University · KR

Funding

Ca2+ signaling and HCO3- secretion by exocrine glandsZIADE000735 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI MUALLEM, SHMUEL · 2010 to 2025
$43.1M
Solute And Water Transport In Renal EpitheliaZIAHL001285 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KNEPPER, MARK · 2009 to 2025
$34.9M
Computational Tools for ProteomicsZIAHL006129 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KNEPPER, MARK · 2011 to 2025
$8.1M
SOLUTE AND WATER TRANSPORT IN RENAL EPITHELIAZ01HL001285 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KNEPPER, MARK A · 1998 to 2008
$3.8M
Intramural NIH HHS Z01 HL001285Intramural NIH HHS ZIA HL001285Intramural NIH HHS ZIA HL006129NHLBI NIH HHS ZIA HL001285NHLBI NIH HHS ZIA HL006129
6 · The paper itself

Abstract

IRBIT is a multifunctional protein that controls the activity of various epithelial ion transporters including NBCe1-B. Interaction with IRBIT increases NBCe1-B activity and exposes two cryptic Cl

Indexed as

AdenosylhomocysteinaseAmino Acid MotifsAnimalsBinding SitesBiotinylationCalcineurinCalcium-Calmodulin-Dependent Protein Kinase Type 2ChlorineHEK293 CellsHumansIon TransportLectins, C-TypeMembrane ProteinsMiceMutationOocytesAdenosylhomocysteinaseCalcineurinCalcium-Calmodulin-Dependent Protein Kinase Type 2ChlorineCLECL1 protein, humanIRBIT protein, mouseLectins, C-TypeMembrane ProteinsProtein Phosphatase 1Protein Serine-Threonine KinasesSerineSLC4A4 protein, humanSlc4a4 protein, mouseSodium-Bicarbonate SymportersSTK39 protein, humanTranscription Factors

Identifiers

PMID30377224
PMCPMC8325875
OpenAlexW2899350210

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.