Evidence map›Paper›PMID 30377223›Full record

ArticleScience signaling2018

RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na

Mykhaylo V Artamonov, Swapnil K Sonkusare, Miranda E Good, Ko Momotani, Masumi Eto, Brant E Isakson, Thu H Le, Eric L Cope, Zygmunt S Derewenda, Urszula Derewenda and 1 more

Open access · greenAbstract read
In one paragraph

Article in Science signaling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Hypotension in hereditary cardiomyopathy.Pflugers Archiv : European journal of physiology · 2022
    Article
  9. Functional Role of Non-Muscle Myosin II in Microglia: An Updated Review.International journal of molecular sciences · 2021
    Review
  10. Multiscale imaging of basal cell dynamics in the functionally mature mammary gland.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Mykhaylo V ArtamonovDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0002-0848-2054
Swapnil K SonkusareDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA.
Miranda E GoodRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA.
Ko MomotaniDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA.
Masumi EtoDepartment of Molecular Physiology and Biophysics, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0002-0651-5836
Brant E IsaksonDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0002-7692-6294
Thu H LeDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA.
Eric L CopeRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0002-1647-808X
Zygmunt S DerewendaDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA.
Urszula DerewendaDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA.
Avril V SomlyoDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA. avs5u@virginia.edu.ORCID 0000-0002-9997-4897
University of Virginia · USOkayama University of Science · JP

Funding

BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6M
Molecular Mechanisms of RhoA-mediated Ca2+Sensitization in Vascular Smooth MuscleR01GM086457 · NIGMS · UNIVERSITY OF VIRGINIA · PI DEREWENDA, URSZULA, DEREWENDA, ZYGMUNT S · 2009 to 2017
$5.4M
Mechanisms of Heterocellular Signaling at the Myoenothelial JunctionR01HL088554 · NHLBI · UNIVERSITY OF VIRGINIA · PI ISAKSON, BRANT E, WEISS, MITCHELL J · 2008 to 2017
$3.8M
Renal Mechanisms of Blood Pressure Regulation and Salt Sensitivity by CollectrinR01DK113632 · NIDDK · UNIVERSITY OF VIRGINIA · PI LE, THU H. · 2017 to 2021
$1.8M
Endothelial TRPV and Potassium Channels Regulate Vascular FunctionR00HL121484 · NHLBI · UNIVERSITY OF VIRGINIA · PI SONKUSARE, SWAPNIL K. · 2015 to 2017
$746k
A novel TRPV4-eNOS signaling pathway in pulmonary endotheliumR56HL138496 · NHLBI · UNIVERSITY OF VIRGINIA · PI SONKUSARE, SWAPNIL K. · 2017 to 2017
$403k
Endothelial TRPV and Potassium Channels Regulate Vascular FunctionK99HL121484 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SONKUSARE, SWAPNIL K. · 2014 to 2014
$128k
Pannexin 1 Channels in Cerebral Arterial Myogenic RegulationF32HL131399 · NHLBI · UNIVERSITY OF VIRGINIA · PI GOOD, MIRANDA E · 2016 to 2017
$71k
NHLBI NIH HHS F32 HL131399NHLBI NIH HHS K99 HL121484NHLBI NIH HHS R00 HL121484NHLBI NIH HHS R01 HL088554NHLBI NIH HHS R56 HL138496NHLBI NIH HHS T32 HL007284NIDDK NIH HHS R01 DK113632NIGMS NIH HHS R01 GM086457
6 · The paper itself

Abstract

Smooth muscle contraction is triggered when Ca

Indexed as

ActinsAnimalsAortaArteriesCalciumCells, CulturedFemaleHydrogen-Ion ConcentrationMaleMiceMice, KnockoutMuscle DevelopmentMuscle, SmoothMyocytes, Smooth MuscleMyographyMyosin-Light-Chain KinaseActinsCalciumMyosin-Light-Chain KinasePhenylephrineribosomal protein S6 kinase, 90kDa, polypeptide 3Ribosomal Protein S6 Kinases, 90-kDaSlc9a1 protein, mouseSmooth Muscle MyosinsSodium-Hydrogen Exchanger 1

Identifiers

PMID30377223
PMCPMC6474246
OpenAlexW2898935800

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.