Evidence map›Paper›PMID 30376999›Full record

ArticleEnvironment international2018

Recent exposure to particle radioactivity and biomarkers of oxidative stress and inflammation: The Framingham Heart Study.

Wenyuan Li, Marguerite M Nyhan, Elissa H Wilker, Carolina L Z Vieira, Honghuang Lin, Joel D Schwartz, Diane R Gold, Brent A Coull, Abdulaziz Mansour Aba, Emelia J Benjamin and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Environment international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  13. Ambient PM gross β-activity and glucose levels during pregnancy.Environmental health : a global access science source · 2021
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  20. Metformin protects against PMRedox biology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Wenyuan LiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Cardiovascular Epidemiology Research Unit, Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Marguerite M NyhanDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Elissa H WilkerDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Cardiovascular Epidemiology Research Unit, Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Carolina L Z VieiraDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Honghuang LinDepartment of Medicine, Boston University School of Medicine, Boston, MA, United States.
Joel D SchwartzDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Diane R GoldDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Brent A CoullDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Abdulaziz Mansour AbaKuwait Institute for Scientific Research, Kuwait City, Kuwait.
Emelia J BenjaminDepartment of Medicine, Boston University School of Medicine, Boston, MA, United States; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, United States; Department of Epidemiology, Boston University School of Public Health, Boston, MA, United States.
Ramachandran S VasanDepartment of Medicine, Boston University School of Medicine, Boston, MA, United States; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, United States; Department of Epidemiology, Boston University School of Public Health, Boston, MA, United States.
Petros KoutrakisDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Murray A MittlemanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Cardiovascular Epidemiology Research Unit, Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States. Electronic address: mmittlem@hsph.harvard.edu.
Harvard University · USBeth Israel Deaconess Medical Center · USBoston University · USBrigham and Women's Hospital · USKuwait Institute for Scientific Research · KW

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
Research Training and Education Core (Core D) P50HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2013 to 2017
$20.1M
Effect of Ambient Particles on Acute Stroke OnsetP01ES009825 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI DOCKERY, DOUGLAS W · 1999 to 2009
$17.4M
Framingham: Inflammation, Genes &Cardiovascular DiseaseR01HL076784 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2004 to 2008
$3.9M
AFGen Consortium: Atrial Fibrillation Genomics to Functional AnalysesR01HL128914 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2015 to 2018
$3.1M
Aging and Inflammation: Longitudinal Markers and Genetics in the Framingham StudyR01AG028321 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2006 to 2010
$1.8M
Traffic pollution, brain structure and cognitive functionR00ES022243 · NIEHS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WILKER, ELISSA · 2016 to 2018
$747k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC025195NHLBI NIH HHS P50 HL120163NHLBI NIH HHS R01 HL076784NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL128914NIA NIH HHS R01 AG028321NIEHS NIH HHS P01 ES009825NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R00 ES022243
6 · The paper itself

Abstract

backgroundDecay products of radioactive materials may attach to ambient fine particles and form radioactive aerosol. Internal ionizing radiation source from inhaled radioactive aerosol may contribute to the fine particulate matter (PM

objectivesTo examine the associations between particle radioactivity and biomarkers of oxidative stress and inflammation among participants from the Framingham Offspring and Third Generation cohorts.

methodsWe included 3996 participants who were not current smokers and lived within 50 km from our central air pollution monitoring station. We estimated regional mean gross beta radioactivity from monitors in the northeastern U.S. as a surrogate for ambient radioactive particles, and calculated the 1- to 28-day moving averages. We used linear regression models for fibrinogen, tumor necrosis factor α, interleukin-6, and myeloperoxidase which were measured once, and linear mixed effect models for 8-epi-prostaglandin F

resultsThe mean age was 54 years and 54% were women. An interquartile range (3 × 10

conclusionsRegional mean particle radioactivity was positively associated with interleukin-6, MCP-1, and P-selectin, but negatively with ICAM-1 and 8-epi-prostaglandin F

Indexed as

Oxidative StressAerosolsAir Pollutants, RadioactiveBiomarkersEnvironmental ExposureFemaleHumansInflammationLinear ModelsLongitudinal StudiesMaleMiddle AgedParticulate MatterSootAerosolsAir Pollutants, RadioactiveBiomarkersParticulate MatterSootEnvironmentEpidemiologyGross beta radiationInflammationOxidative stressParticle radioactivity

Identifiers

PMID30376999
PMCPMC6279550
OpenAlexW2898086380

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.