ArticleRedox report : communications in free radical research2018
Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus.
Article in Redox report : communications in free radical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- The role of hypoglycemic phytochemicals in improving male reproductive dysfunction: a systematic review of preclinical evidence.Frontiers in endocrinology · 2026Pooled it
- Effect of low-level laser therapy on seminiferous epithelium: a systematic review of in vivo studies.Lasers in medical science · 2021Pooled it
- Understanding the impact of streptozotocin on diabetic male infertility: perspectives from rodent models and pharmacological networking.BMC pharmacology & toxicology · 2025Review
- Myoinositol improves sperm parameters in diabetic rats by reducing oxidative stress and regulating apoptosis-related genes.Journal of molecular histology · 2025Article
- Oxytocin ameliorates lipopolysaccharide-induced acute orchitis model: interplay of oxidative stress and inflammatory pathways.Frontiers in pharmacology · 2024Article
- Phytochemicals: Alternative for Infertility Treatment and Associated Conditions.Oxidative medicine and cellular longevity · 2023Review
- Protective properties ofInternational journal of reproductive biomedicine · 2022Article
- Clinical Application of Bioextracts in Supporting the Reproductive System of Animals and Humans: Potential and Limitations.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Evaluation of testicular glycogen storage, FGF21 and LDH expression and physiological parameters of sperm in hyperglycemic rats treated with hydroalcoholic extract of Securigera Securidaca seeds, and Glibenclamide.Reproductive biology and endocrinology : RB&E · 2021Article
- Effect ofJournal of diabetes and metabolic disorders · 2021Article
- Author's Reply.International journal of reproductive biomedicine · 2021Article
- Exertional heat stroke on fertility, erectile function, and testicular morphology in male rats.Scientific reports · 2021Article
- Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential.Antioxidants (Basel, Switzerland) · 2020Review
- Article
- Protective Role ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesLoranthus micranthus is widely used in Nigerian folklore treatment of male infertility and diabetes complications. We investigated this claim in rats rendered diabetic by streptozotocin (STZ).
methodsInduction of diabetes mellitus in adult male Wistar rats was by intraperitoneal injection of STZ (60 mg/kg). The diabetic rats were thereafter treated orally once/day with 5 mg/kg Gilbenclamide or L. micranthus (100 mg/kg or 200 mg/kg) and monitored for 14 days. Clinical observations, hormonal profile, oxidative stress parameters, glucose metabolism enzymes, histopathological examination, apoptotic marker immunoreactivity and western blotting in testes and sperm parameters were evaluated to examine effects of L. micranthus on STZ-diabetic rats.
resultsL. micranthus treatment significantly reduced the blood glucose level (45.9% and 84.7% on the 7th and 14th post-treatment days, respectively); increased antioxidant status, improved microarchitecture of testes, reduced lipid peroxidation and increased BCl-2 protein expression in diabetic rats relative to control. Furthermore, treatment with L. micranthus increased steroidogenic enzymes activities, levels of steroid hormones and improved sperm quality, relative to control.
conclusionThe anti-diabetic and aphrodisiac properties exhibited by L. micranthus could be contingent on its ability to restore a balance to the compromised redox status that characterizes male reproductive dysfunction in diabetes.
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Registered trials
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