Evidence map›Paper›PMID 30376747›Full record

Trial reportJournal of the American Heart Association2018

Body Mass Index, Natriuretic Peptides, and Risk of Adverse Outcomes in Patients With Heart Failure and Preserved Ejection Fraction: Analysis From the TOPCAT Trial.

Ambarish Pandey, Jarett D Berry, Mark H Drazner, James C Fang, W H Wilson Tang, Justin L Grodin

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Biomarkers in Heart Failure: A Review and a Wish.International journal of molecular sciences · 2025
    Review
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Review
  13. Range of adiposity and cardiorenal syndrome.World journal of diabetes · 2020
    Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ambarish Pandey1 Division of Cardiology Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX.
Jarett D Berry1 Division of Cardiology Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX.
Mark H Drazner1 Division of Cardiology Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX.
James C Fang2 Division of Cardiovascular Medicine University of Utah Health Sciences Center Salt Lake City UT.
W H Wilson Tang3 Kaufman Center for Heart Failure Department of Cardiovascular Medicine, Heart and Vascular Institute Cleveland Clinic Cleveland OH.
Justin L Grodin1 Division of Cardiology Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background The prognostic interrelationship between natriuretic peptide ( NP ) levels and body mass index ( BMI ) among patients with chronic stable heart failure with preserved ejection fraction is not well characterized. Methods and Results Participants from the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) trial enrolled in the Americas meeting inclusion by the NP stratum were stratified into 4 data-derived categories by BMI and standardized NP -z score. Adjusted Cox-proportional models determined the independent association of BMI , NP -z score, and BMI / NP categories with composite primary end point, heart failure hospitalization, and all-cause mortality. The study population included 997 participants. There was a U-shaped relationship between BMI and NP with elevated NP levels noted at extremes of BMI distribution. There was also a U-shaped relationship between BMI and risk of adverse clinical outcomes with the lowest risk among patients approximating a BMI of 25 kg/m

Indexed as

Stroke VolumeAgedAged, 80 and overBody Mass IndexDouble-Blind MethodFemaleHeart FailureHumansMaleMineralocorticoid Receptor AntagonistsNatriuretic PeptidesRisk AssessmentTreatment OutcomeMineralocorticoid Receptor AntagonistsNatriuretic Peptidesbrain natriuretic peptideheart failureobesity

Identifiers

PMID30376747
PMCPMC6404179

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.