ArticleCirculation. Arrhythmia and electrophysiology2018
Critical Volume of Human Myocardium Necessary to Maintain Ventricular Fibrillation.
Article in Circulation. Arrhythmia and electrophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Optical mapping: pioneering the frontier of preclinical antiarrhythmic drug evaluation.iScience · 2026Review
- Simultaneous electromechanical monitoring in engineered heart tissues using a mesoscale framework.Science advances · 2024Article
- Significance of J waves in unexplained ventricular fibrillation among elderly populations with various comorbidities.Heart rhythm O2 · 2024Article
- Hardware-Mappable Cellular Neural Networks for Distributed Wavefront Detection in Next-Generation Cardiac Implants.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2022Article
- Electrophysiology and Arrhythmogenesis in the Human Right Ventricular Outflow Tract.Circulation. Arrhythmia and electrophysiology · 2022Article
- Review
- Theoretical Models and Computational Analysis of Action Potential Dispersion for Cardiac Arrhythmia Risk Stratification.Frontiers in cardiovascular medicine · 2021Article
- Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery.Nature biomedical engineering · 2020Article
- Prolonged ursodeoxycholic acid administration reduces acute ischaemia-induced arrhythmias in adult rat hearts.Scientific reports · 2020Article
- Granger Causality-Based Analysis for Classification of Fibrillation Mechanisms and Localization of Rotational Drivers.Circulation. Arrhythmia and electrophysiology · 2020Article
- Article
- Optocardiography and Electrophysiology Studies of Ex Vivo Langendorff-perfused Hearts.Journal of visualized experiments : JoVE · 2019Article
- Spontaneous termination of chaotic spiral wave dynamics in human cardiac ion channel models.PloS one · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAbnormal QT intervals, long QT or short QT, have been epidemiologically linked with sudden cardiac death because of ventricular fibrillation (VF). Consequently, Food and Drug Administration recommends testing all pharmacological agents for QT toxicity as a risk factor for cardiac toxicity. Such tests assess QT/QTc interval, which represents ventricular depolarization and repolarization. However, the current QT toxicity analysis does not account for the well-known anisotropy in cardiac tissue conductivity. Mines demonstrated in 1913 that cardiac wavelength (λ) determines inducibility of reentrant arrhythmia, where both repolarization time or action potential duration and conduction velocity determine λ=action potential duration×conduction velocity. We aimed to determine the role of anisotropic wavelength in inducibility of VF in explanted human left ventricular preparations. We tested the hypothesis that 3-dimensional cardiac wavelength, which takes into account anisotropic cardiac tissue conductivity, can accurately predict VF sustainability.
methodsWe conducted panoramic optical mapping of coronary perfused human left ventricular wedge preparations subjected to pharmacologically induced shortening and prolongation of action potential duration, by I
resultsAt baseline, at pacing rate of 240 beats per minute, the wavelengths were λ
conclusionsSustained VF was only sustained in ventricular volume exceeding critical V
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.