ArticleAngewandte Chemie (International ed. in English)2018
Non-Peptidic Cell-Penetrating Motifs for Mitochondrion-Specific Cargo Delivery.
Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Kinetoplast-Directed Therapies: A Selective Mitochondrial Approach to Combat Leishmaniasis.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Photothermal-assisted NHNature communications · 2025Article
- Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex.Drug delivery · 2022Article
- Unraveling the Pivotal Role of Atropisomerism for Cellular Internalization.Journal of the American Chemical Society · 2022Article
- Mitochondria targeting drugs for neurodegenerative diseases-Design, mechanism and application.Acta pharmaceutica Sinica. B · 2022Review
- A manganese (II)-based coordinative dendrimer with robust efficiency in intracellular peptide delivery.Bioactive materials · 2022Article
- How Do Biomolecules Cross the Cell Membrane?Accounts of chemical research · 2022Article
- Assessing the Cellular Uptake, Endosomal Escape, and Cytosolic Entry Efficiencies of Cyclic Peptides.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Cellular- and Subcellular-Targeted Delivery Using a Simple All-in-One Polymeric Nanoassembly.Angewandte Chemie (International ed. in English) · 2020Article
- Improving the Stability of Maleimide-Thiol Conjugation for Drug Targeting.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Cell-Penetrating Peptides Escape the Endosome by Inducing Vesicle Budding and Collapse.ACS chemical biology · 2020Article
- Cell-penetrating and mitochondrion-targeting molecules.Methods in enzymology · 2020Article
- De novo Design of Selective Membrane-Active Peptides by Enzymatic Control of Their Conformational Bias on the Cell Surface.Angewandte Chemie (International ed. in English) · 2019Article
- Understanding Cell Penetration of Cyclic Peptides.Chemical reviews · 2019Review
- Targeting and Imaging of Mitochondria Using Near-Infrared Cyanine Dye and Its Application to Multicolor Imaging.ACS omega · 2019Article
- Overcoming Endosomal Entrapment in Drug Delivery.Bioconjugate chemistry · 2019Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Mitochondrial dysfunction is linked to a variety of human illnesses, but selective delivery of therapeutics into the mitochondrion is challenging. Now a family of amphipathic cell-penetrating motifs (CPMs) is presented, consisting of four guanidinium groups and one or two aromatic hydrophobic groups (naphthalene) assembled through a central scaffold (a benzene ring). The CPMs and CPM-cargo conjugates efficiently enter the interior of cultured mammalian cells and are specifically localized into the mitochondrial matrix, as revealed by high-resolution confocal microscopy. With a membrane-impermeable peptide as cargo, the CPMs exhibited ≥170-fold higher delivery efficiency than previous mitochondrial delivery vehicles. Conjugation of a small-molecule inhibitor of heat shock protein 90 to a CPM resulted in accumulation of the inhibitor inside the mitochondrial matrix with greatly enhanced anticancer activity. The CPMs showed minimal effect on the viability or the mitochondrial membrane potential of mammalian cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.