Evidence map›Paper›PMID 30376411›Full record

ArticleRadiation research2019

Enhanced Pharmacological Ascorbate Oxidation Radiosensitizes Pancreatic Cancer.

Matthew S Alexander, Brianne R O'Leary, Justin G Wilkes, Adrienne R Gibson, Brett A Wagner, Juan Du, Ehab Sarsour, Rosa F Hwang, Garry R Buettner, Joseph J Cullen

Abstract read
In one paragraph

Article in Radiation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer.Journal of experimental & clinical cancer research : CR · 2021
    Review
  10. Review
  11. Impact of EcSOD Perturbations in Cancer Progression.Antioxidants (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Matthew S Alexandera   Department of Surgery, University of Iowa, Iowa City, Iowa.
Brianne R O'Learya   Department of Surgery, University of Iowa, Iowa City, Iowa.
Justin G Wilkesa   Department of Surgery, University of Iowa, Iowa City, Iowa.
Adrienne R Gibsonb   Free Radical and Radiation Biology Program, University of Iowa, Iowa City, Iowa.
Brett A Wagnerb   Free Radical and Radiation Biology Program, University of Iowa, Iowa City, Iowa.
Juan Dua   Department of Surgery, University of Iowa, Iowa City, Iowa.
Ehab Sarsourb   Free Radical and Radiation Biology Program, University of Iowa, Iowa City, Iowa.
Rosa F Hwangc   Breast Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Garry R Buettnerb   Free Radical and Radiation Biology Program, University of Iowa, Iowa City, Iowa.
Joseph J Cullena   Department of Surgery, University of Iowa, Iowa City, Iowa.
University of Iowa · USThe University of Texas MD Anderson Cancer Center · USVeterans Health Administration · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Project 3: MRI Imaging of Redox Active Fe Predicts GBM Responses to Pharmacological AscorbateP01CA217797 · NCI · UNIVERSITY OF IOWA · PI BUATTI, JOHN M · 2018 to 2022
$9.6M
TRAINING PROGRAM IN FREE RADICAL AND RADIATION BIOLOGYT32CA078586 · NCI · UNIVERSITY OF IOWA · PI SPITZ, DOUGLAS ROBERT · 1999 to 2024
$5.7M
University of Iowa Surgical Oncology Training GrantT32CA148062 · NCI · UNIVERSITY OF IOWA · PI WEIGEL, RONALD J · 2010 to 2020
$3.8M
The chemical biology of pharmacological ascorbate in cancer treatmentR01CA169046 · NCI · UNIVERSITY OF IOWA · PI BUETTNER, GARRY R · 2013 to 2017
$1.6M
Pharmacological Ascorbate as a Radiosensitizer in Pancreatic CancerR01CA184051 · NCI · UNIVERSITY OF IOWA · PI CULLEN, JOSEPH J · 2015 to 2018
$1.4M
NCI NIH HHS P01 CA217797NCI NIH HHS P30 CA086862NCI NIH HHS R01 CA169046NCI NIH HHS R01 CA184051NCI NIH HHS T32 CA078586NCI NIH HHS T32 CA148062
6 · The paper itself

Abstract

Pharmacologic ascorbate (P-AscH

Indexed as

AnimalsAscorbic AcidCell Line, TumorDisease Models, AnimalDrug SynergismElectron Spin Resonance SpectroscopyHumansMetalloporphyrinsOxidation-ReductionPancreatic NeoplasmsRadiation-Sensitizing AgentsAscorbic AcidMetalloporphyrinsRadiation-Sensitizing Agentstetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex

Identifiers

PMID30376411
PMCPMC6441967
OpenAlexW2899493457

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.