ArticleThe Journal of infectious diseases2019
FUT2 Genetic Variants and Reported Respiratory and Gastrointestinal Illnesses During Infancy.
Article in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Why Are Some Children More Sick Than Others? Lessons From Genome-wide Association Studies of Respiratory Viral Infections.The Pediatric infectious disease journal · 2026Article
- Influence of infant fucosyltransferase polymorphisms on the association of maternal secretor status with child outcomes: the Ulm birth cohort studies.Scientific reports · 2025Article
- Vitamin D-FUT2 interaction and risk of lower respiratory tract infections in childhood.Allergy · 2025Article
- Urban metabolic and airway immune profiles increase the risk of infections in early childhood.Thorax · 2024Article
- Human breastmilk memory T cells throughout lactation manifest activated tissue-oriented profile with prominent regulation.JCI insight · 2024Article
- Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.Nature genetics · 2023Article
- Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection.The European respiratory journal · 2023Article
- Biology of human milk oligosaccharides: From basic science to clinical evidence.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2022Review
- Analysing the protection from respiratory tract infections and allergic diseases early in life by human milk components: the PRIMA birth cohort.BMC infectious diseases · 2022Observational
- Human Milk Oligosaccharides: Potential Applications in COVID-19.Biomedicines · 2022Review
- Effects of addition of 2-fucosyllactose to infant formula on growth and specific pathways of utilization byFrontiers in nutrition · 2022Article
- FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses.Nature communications · 2020Article
- Do Human Milk Oligosaccharides Protect Against Infant Atopic Disorders and Food Allergy?Nutrients · 2020Article
- Low lung function in the developing world is analogous to stunting: a review of the evidence.Wellcome open research · 2020Article
- The nasopharyngeal microbiome and LRTIs in infants.The Lancet. Respiratory medicine · 2019Article
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundFucosyltransferase 2 (FUT2) controls the production of digestive and respiratory epithelia of histo-blood group antigens involved in the attachment of pathogens. The aim of our study was to relate FUT2 variants to reported gastrointestinal and respiratory illnesses in infancy.
methodsIn the Southampton Women's Survey, FUT2 genetic variants (single-nucleotide polymorphisms [SNPs] rs601338 and rs602662) were genotyped in 1831 infants and related to infant illnesses, after adjustment for sex, breastfeeding duration, and potential confounders.
resultsFor FUT2 SNP rs601338, the risk ratios for ≥1 bout of diarrhea during ages 6-12 months and ages 12-24 months per additional risk (G) allele were 1.23 (95% confidence interval [CI], 1.08-1.4; P = .002) and 1.41 (95% CI, 1.24-1.61; P = 1.7 × 10-7), respectively; the risk ratio for ≥1 diagnosis of a lower respiratory illness (ie, pneumonia or bronchiolitis) during ages 12-24 months per additional G allele was 2.66 (95% CI, 1.64-4.3; P = .00007). Similar associations were found between rs602662 and gastrointestinal and respiratory illnesses, owing to the high linkage disequilibrium with rs601338 (R2 = 0.92). Longer breastfeeding duration predicted a lower risk of diarrhea, independent of infant FUT2 genotype.
conclusionsWe confirmed that FUT2 G alleles are associated with a higher risk of infant gastrointestinal illnesses and identified novel associations with respiratory illnesses. FUT2 locus variants need consideration in future studies of gastrointestinal and respiratory illnesses among infants.
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