SynthesisSchizophrenia bulletin2019
Childhood Trauma and Neurocognition in Adults With Psychotic Disorders: A Systematic Review and Meta-analysis.
Synthesis in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 5 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- The shadow of trauma: impaired mentalization in clinical populations - a systematic review.Psychological medicine · 2025Pooled it
- Integrating Clinical Neuropsychology and Psychotic Spectrum Disorders: A Systematic Analysis of Cognitive Dynamics, Interventions, and Underlying Mechanisms.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Association Between Childhood Adversity and Functional Outcomes in People With Psychosis: A Meta-analysis.Schizophrenia bulletin · 2023Pooled it
- Cognitive impairment in people with schizophrenia: an umbrella review.European archives of psychiatry and clinical neuroscience · 2022Pooled it
- Childhood trauma and hippocampal-dependent memory across the psychosis spectrum: a systematic review and meta-analysis.Journal of psychiatry & neuroscience : JPNPooled it
- Childhood Trauma and Frontoparietal Network Connectivity During Working Memory Task Performance in Individuals With Schizophrenia and Healthy Participants.The European journal of neuroscience · 2026Article
- Dissociation, Childhood Trauma, and Emotion Processing in Individuals with Elevated Psychosis-like Experiences: A Theoretical Framework of Cognitive Integration.Brain sciences · 2026Article
- Evaluating psychosis-specific effects of trauma exposure in early-onset and adult-onset psychosis.Psychological medicine · 2026Article
- Childhood Maltreatment and Cognitive Performance in Bipolar Disorder: The Potential Role of Inflammation.Acta psychiatrica Scandinavica · 2026Article
- How Psychological Trauma Affects Cognitive Functions: A Systematic Review and Meta-Analysis.Clinical neuropsychiatry · 2026Article
- Mapping the Interplay Between Childhood Trauma, Substance Use, and Psychopathology in Early Psychosis: A Network Analysis Approach.Schizophrenia bulletin · 2026Article
- Synergistic pathways to psychosis: understanding developmental risk and resilience factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Nonlinear associations between reported childhood trauma and cognitive impairment in schizophrenia spectrum disorders.Schizophrenia research · 2025Article
- Impact of childhood trauma and parental socialization on at-risk mental state in non-clinical adolescents.World journal of psychiatry · 2025Article
- Childhood adverse events and their association with psychotic symptoms and quality of life in young adults with first episode psychosis and unaffected siblings.Schizophrenia research · 2025Article
- Exploring the Interactions Between Psychotic Symptoms, Cognition, and Environmental Risk Factors: A Bayesian Analysis of Networks.Schizophrenia bulletin · 2025Article
- Stress sensitivity, negative affect, and functioning in an early psychosis clinic.Schizophrenia research · 2025Article
- A systematic review and meta-analysis of the traumatogenic phenotype hypothesis of psychosis: commentary, Alameda.BJPsych open · 2025Article
- The impact of parenting styles on depression among high-risk adolescents of different genders in chinese urban samples: the mediating effects of adverse childhood experiences and learning burnout.Frontiers in psychiatry · 2025Article
- Working memory performance is related to childhood trauma but not psychotic-like experiences in a nonpsychiatric sample.Psychological trauma : theory, research, practice and policy · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCharacterizing the link between childhood trauma and adult neurocognitive function in psychosis is crucial for improving the fields understanding of how early environmental risk factors impact the presentation of the disorder. To date, the literature has been inconsistent: meta-analytic synthesis is lacking, and it is unclear whether specific cognitive functions are affected.
methodsA meta-analysis was performed on a total of 3315 subjects with a psychotic disorder. The links between childhood trauma, overall neurocognitive function, and four cognitive subdomains (working memory, executive function, verbal/visual memory, and attention/processing speed) were examined. Relevant sample characteristics and methodological moderators were tested. The strength of the association between trauma and overall neurocognition in individuals with psychotic disorders was also compared to that of healthy controls.
resultsAmong individuals with psychotic disorders, there was a significant association between overall cognition and childhood trauma, r = -.055; 95% CI = -0.09, -0.02, P = .002. There was also a modest, negative relationship between childhood trauma and working memory, r = -.091; 95% CI = -0.15, -0.03, P = .002. Moderators did not have a significant effect on these analyses. Further, the association between childhood trauma and neurocognition was significantly stronger in healthy controls compared to patients with a psychotic disorder.
conclusionA small negative association was found between overall cognition and childhood trauma in individuals with psychotic disorders. Results suggest the association is less strong for individuals with a psychotic disorder compared to healthy populations. Findings are informative for prominent etiological models of psychosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.