Evidence map›Paper›PMID 30375913›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020

Divergent metabolic substrate utilization in brain during epileptogenesis precedes chronic hypometabolism.

Pablo Bascuñana, Mirjam Brackhan, Ina Leiter, Heike Keller, Ina Jahreis, Tobias L Ross, Frank M Bengel, Marion Bankstahl, Jens P Bankstahl

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Astrocytic CaGlia · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. TSPO PET Identifies Different Anti-inflammatory Minocycline Treatment Response in Two Rodent Models of Epileptogenesis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Pablo BascuñanaDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-2186-8899
Mirjam BrackhanDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Ina LeiterDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Heike KellerDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Ina JahreisDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Tobias L RossDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Frank M BengelDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Marion BankstahlDepartment of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover, Germany.
Jens P BankstahlDepartment of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
University of Veterinary Medicine Hannover, Foundation · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations in metabolism during epileptogenesis may be a therapy target. Recently, an increase in amino acid transport into the brain was proposed to play a role in epileptogenesis. We aimed to characterize alterations of substrate utilization during epileptogenesis and in chronic epilepsy. The lithium-pilocarpine post status epilepticus (SE) rat model was used. We performed longitudinal O-(2-[(18)F]fluoroethyl)-l-tyrosine (

Indexed as

Amino AcidsAmygdalaAnimalsBrainBrain Diseases, MetabolicChronic DiseaseDisease Models, AnimalEpilepsyFluorine RadioisotopesFluorodeoxyglucose F18HippocampusPositron-Emission TomographyRatsSubstrate SpecificityAmino AcidsFluorine-18Fluorine RadioisotopesFluorodeoxyglucose F18Amino acid turnoverepilepsyfluorodeoxyglucosefluoroethyl-l-tyrosinepositron emission tomography

Identifiers

PMID30375913
PMCPMC6928550
OpenAlexW2899182787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.