Evidence map›Paper›PMID 30375896›Full record

ReviewExpert review of proteomics2018

Nanoproteomics comes of age.

Ying Zhu, Paul D Piehowski, Ryan T Kelly, Wei-Jun Qian

Abstract readReviewVideo-Audio Media
In one paragraph

Review in Expert review of proteomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Mass Spectrometry-based Solutions for Single-cell Proteomics.Genomics, proteomics & bioinformatics · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Gold Nanoparticles Contact with Cancer Cell: A Brief Update.International journal of molecular sciences · 2022
    Review
  14. Infrared Laser Ablation Microsampling with a Reflective Objective.Journal of the American Society for Mass Spectrometry · 2022
    Article
  15. Article
  16. Review
  17. Article
  18. Single-cell Proteomics: Progress and Prospects.Molecular & cellular proteomics : MCP · 2020
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ying Zhua Environmental and Molecular Sciences Laboratory, Pacific Northwest National Laboratory , Richland , WA , USA.ORCID 0000-0002-5416-0566
Paul D Piehowskib Biological Sciences Division , Pacific Northwest National Laboratory , Richland , WA , USA.
Ryan T Kellya Environmental and Molecular Sciences Laboratory, Pacific Northwest National Laboratory , Richland , WA , USA.
Wei-Jun Qianb Biological Sciences Division , Pacific Northwest National Laboratory , Richland , WA , USA.ORCID 0000-0002-5393-2827

Funding

Regulatory Networks and Biomarkers of Beta-cell Dysfunction and ApoptosisUC4DK104167 · NIDDK · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI KULKARNI, ROHIT N., MATHEWS, CLAYTON E · 2014 to 2016
$2.7M
Serum protein biomarkers for predicting type 1 diabetesDP3DK110844 · NIDDK · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI QIAN, WEI-JUN · 2016 to 2016
$1.8M
Area A: In-Depth Proteome Mapping of the Tumor Microenvironment with Single-Cell ResolutionR33CA225248 · NCI · BRIGHAM YOUNG UNIVERSITY · PI KELLY, RYAN T · 2017 to 2017
$1.7M
High-throughput multidimensional bioseparations for next-generation proteomicsR21EB020976 · NIBIB · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI KELLY, RYAN T · 2016 to 2017
$400k
NCI NIH HHS R33 CA225248NIBIB NIH HHS R21 EB020976NIDDK NIH HHS DP3 DK110844NIDDK NIH HHS UC4 DK104167
6 · The paper itself

Abstract

introductionNanoproteomics, which is defined as quantitative proteome profiling of small populations of cells (<5000 cells), can reveal critical information related to rare cell populations, hard-to-obtain clinical specimens, and the cellular heterogeneity of pathological tissues. Areas covered: We present a brief review of the recent technological advances in nanoproteomics. These advances include new technologies or approaches covering major areas of proteomics workflow ranging from sample isolation, sample processing, high-resolution separations, to MS instrumentation. Expert commentary: We comment on the current state of nanoproteomics and discuss perspectives on both future technological directions and potential enabling applications.

Indexed as

AnimalsChromatography, LiquidElectrophoresis, CapillaryLaser Capture MicrodissectionMammalsNanotechnologyProtein Processing, Post-TranslationalProteomicsSingle-Cell AnalysisSpectrometry, Mass, Electrospray IonizationWorkflownanoPOTSNanoproteomicssingle cell proteomics

Identifiers

PMID30375896
PMCPMC6415674

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.