Evidence map›Paper›PMID 30375837›Full record

SynthesisJournal of psychiatry & neuroscience : JPN2018

Psychoradiological patterns of small-world properties and a systematic review of connectome studies of patients with 6 major psychiatric disorders

Xueling Suo, Du Lei, Lei Li, Wenbin Li, Jing Dai, Song Wang, Manxi He, Hongyan Zhu, Graham J. Kemp, Qiyong Gong

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of psychiatry & neuroscience : JPN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Changes in the structural brain connectome over the course of a nonrandomized clinical trial for acute mania.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Trial
  4. Changes in the brain structural connectome after a prospective randomized clinical trial of lithium and quetiapine treatment in youth with bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Trial
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  19. Individualized morphological covariation network aberrance associated with seizure relapse after antiseizure medication withdrawal.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Xueling Suo *From the Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041 China (Suo, Lei, Li, Gong); the Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK (Lei); the Department of Psychoradiology, Chengdu Mental Health Center, Chengdu, Sichuan, China (Dai, Wang, He); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Zhu); the Liverpool Magnetic Resonance Imaging Centre (LiMRIC) and Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK (Kemp); and the Department of Psychology, School of Public Administration, Sichuan University, Chengdu, Sichuan, China (Gong).
Du Lei *From the Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041 China (Suo, Lei, Li, Gong); the Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK (Lei); the Department of Psychoradiology, Chengdu Mental Health Center, Chengdu, Sichuan, China (Dai, Wang, He); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Zhu); the Liverpool Magnetic Resonance Imaging Centre (LiMRIC) and Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK (Kemp); and the Department of Psychology, School of Public Administration, Sichuan University, Chengdu, Sichuan, China (Gong).
Lei Li *From the Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041 China (Suo, Lei, Li, Gong); the Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK (Lei); the Department of Psychoradiology, Chengdu Mental Health Center, Chengdu, Sichuan, China (Dai, Wang, He); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Zhu); the Liverpool Magnetic Resonance Imaging Centre (LiMRIC) and Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK (Kemp); and the Department of Psychology, School of Public Administration, Sichuan University, Chengdu, Sichuan, China (Gong).
Wenbin Li *From the Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041 China (Suo, Lei, Li, Gong); the Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK (Lei); the Department of Psychoradiology, Chengdu Mental Health Center, Chengdu, Sichuan, China (Dai, Wang, He); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Zhu); the Liverpool Magnetic Resonance Imaging Centre (LiMRIC) and Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK (Kemp); and the Department of Psychology, School of Public Administration, Sichuan University, Chengdu, Sichuan, China (Gong).
Jing Dai *From the Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041 China (Suo, Lei, Li, Gong); the Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK (Lei); the Department of Psychoradiology, Chengdu Mental Health Center, Chengdu, Sichuan, China (Dai, Wang, He); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Zhu); the Liverpool Magnetic Resonance Imaging Centre (LiMRIC) and Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK (Kemp); and the Department of Psychology, School of Public Administration, Sichuan University, Chengdu, Sichuan, China (Gong).
Song Wang *From the Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041 China (Suo, Lei, Li, Gong); the Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK (Lei); the Department of Psychoradiology, Chengdu Mental Health Center, Chengdu, Sichuan, China (Dai, Wang, He); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Zhu); the Liverpool Magnetic Resonance Imaging Centre (LiMRIC) and Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK (Kemp); and the Department of Psychology, School of Public Administration, Sichuan University, Chengdu, Sichuan, China (Gong).
Manxi He *From the Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041 China (Suo, Lei, Li, Gong); the Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK (Lei); the Department of Psychoradiology, Chengdu Mental Health Center, Chengdu, Sichuan, China (Dai, Wang, He); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Zhu); the Liverpool Magnetic Resonance Imaging Centre (LiMRIC) and Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK (Kemp); and the Department of Psychology, School of Public Administration, Sichuan University, Chengdu, Sichuan, China (Gong).
Hongyan Zhu *From the Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041 China (Suo, Lei, Li, Gong); the Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK (Lei); the Department of Psychoradiology, Chengdu Mental Health Center, Chengdu, Sichuan, China (Dai, Wang, He); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Zhu); the Liverpool Magnetic Resonance Imaging Centre (LiMRIC) and Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK (Kemp); and the Department of Psychology, School of Public Administration, Sichuan University, Chengdu, Sichuan, China (Gong).
Graham J. Kemp *From the Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041 China (Suo, Lei, Li, Gong); the Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK (Lei); the Department of Psychoradiology, Chengdu Mental Health Center, Chengdu, Sichuan, China (Dai, Wang, He); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Zhu); the Liverpool Magnetic Resonance Imaging Centre (LiMRIC) and Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK (Kemp); and the Department of Psychology, School of Public Administration, Sichuan University, Chengdu, Sichuan, China (Gong).
Qiyong Gong *From the Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041 China (Suo, Lei, Li, Gong); the Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK (Lei); the Department of Psychoradiology, Chengdu Mental Health Center, Chengdu, Sichuan, China (Dai, Wang, He); the Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China (Zhu); the Liverpool Magnetic Resonance Imaging Centre (LiMRIC) and Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK (Kemp); and the Department of Psychology, School of Public Administration, Sichuan University, Chengdu, Sichuan, China (Gong).
West China Hospital of Sichuan University · CNPublic Health Clinical Center of Chengdu · CNSichuan University · CNUniversity of Liverpool · GBKing's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Brain connectome research based on graph theoretical analysis shows that small-world topological properties play an important role in the structural and functional alterations observed in patients with psychiatric disorders. However, the reported global topological alterations in small-world properties are controversial, are not consistently conceptualized according to agreed-upon criteria, and are not critically examined for consistent alterations in patients with each major psychiatric disorder. Methods: Based on a comprehensive PubMed search, we systematically reviewed studies using noninvasive neuroimaging data and graph theoretical approaches for 6 major psychiatric disorders: schizophrenia, major depressive disorder (MDD), attention-deficit/hyperactivity disorder (ADHD), bipolar disorder (BD), obsessive–compulsive disorder (OCD) and posttraumatic stress disorder (PTSD). Here, we describe the main patterns of altered small-world properties and then systematically review the evidence for these alterations in the structural and functional connectome in patients with these disorders. Results: We selected 40 studies of schizophrenia, 33 studies of MDD, 5 studies of ADHD, 5 studies of BD, 7 studies of OCD and 5 studies of PTSD. The following 4 patterns of altered small-world properties are defined from theperspectives of segregation and integration: "regularization," "randomization," "stronger small-worldization" and "weaker small-worldization." Although more differences than similarities are noted in patients with these disorders, a prominent trend is the structural regularization versus functional randomization in patients with schizophrenia. Limitations: Differences in demographic and clinical characteristics, preprocessing steps and analytical methods can produce contradictory results, increasing the difficulty of integrating results across different studies. Conclusion: Four psychoradiological patterns of altered small-world properties are proposed. The analysis of altered smallworld properties may provide novel insights into the pathophysiological mechanisms underlying psychiatric disorders from a connectomic perspective. In future connectome studies, the global network measures of both segregation and integration should be calculated to fully evaluate altered small-world properties in patients with a particular disease.

Indexed as

ConnectomeHumansMental DisordersNeural PathwaysNeuroimaging

Identifiers

PMID30375837
PMCPMC6203546
OpenAlexW2899762306

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.